A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)
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Аутори
Todoric-Živanović, BMarisavljevic, D
Surace, C
Cemerikic, V
Markovic, O
Krtolica-Žikić, Koviljka
Tatomirovic, Z
Cikota, B
Magic, Z
Rocchi, M
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Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or masked BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9) (p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21. (c) 2006 Elsevier Inc. All rights reserved.
Извор:
Cancer Genetics and Cytogenetics, 2006, 166, 2, 180-185
DOI: 10.1016/j.cancergencyto.2005.11.008
ISSN: 0165-4608
PubMed: 16631477
WoS: 000237174400014
Scopus: 2-s2.0-33646490448
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Институција/група
VinčaTY - JOUR AU - Todoric-Živanović, B AU - Marisavljevic, D AU - Surace, C AU - Cemerikic, V AU - Markovic, O AU - Krtolica-Žikić, Koviljka AU - Tatomirovic, Z AU - Cikota, B AU - Magic, Z AU - Rocchi, M PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3011 AB - Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or masked BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9) (p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21. (c) 2006 Elsevier Inc. All rights reserved. T2 - Cancer Genetics and Cytogenetics T1 - A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1) VL - 166 IS - 2 SP - 180 EP - 185 DO - 10.1016/j.cancergencyto.2005.11.008 ER -
@article{ author = "Todoric-Živanović, B and Marisavljevic, D and Surace, C and Cemerikic, V and Markovic, O and Krtolica-Žikić, Koviljka and Tatomirovic, Z and Cikota, B and Magic, Z and Rocchi, M", year = "2006", abstract = "Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or masked BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9) (p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21. (c) 2006 Elsevier Inc. All rights reserved.", journal = "Cancer Genetics and Cytogenetics", title = "A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)", volume = "166", number = "2", pages = "180-185", doi = "10.1016/j.cancergencyto.2005.11.008" }
Todoric-Živanović, B., Marisavljevic, D., Surace, C., Cemerikic, V., Markovic, O., Krtolica-Žikić, K., Tatomirovic, Z., Cikota, B., Magic, Z.,& Rocchi, M.. (2006). A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1). in Cancer Genetics and Cytogenetics, 166(2), 180-185. https://doi.org/10.1016/j.cancergencyto.2005.11.008
Todoric-Živanović B, Marisavljevic D, Surace C, Cemerikic V, Markovic O, Krtolica-Žikić K, Tatomirovic Z, Cikota B, Magic Z, Rocchi M. A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1). in Cancer Genetics and Cytogenetics. 2006;166(2):180-185. doi:10.1016/j.cancergencyto.2005.11.008 .
Todoric-Živanović, B, Marisavljevic, D, Surace, C, Cemerikic, V, Markovic, O, Krtolica-Žikić, Koviljka, Tatomirovic, Z, Cikota, B, Magic, Z, Rocchi, M, "A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)" in Cancer Genetics and Cytogenetics, 166, no. 2 (2006):180-185, https://doi.org/10.1016/j.cancergencyto.2005.11.008 . .