Show simple item record

dc.creatorJovanović, Predrag
dc.creatorPuškaš, Nela
dc.creatorStefanović, Bojana
dc.creatorSpasojević, Nataša
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T15:44:45Z
dc.date.available2018-03-01T15:44:45Z
dc.date.issued2014
dc.identifier.issn0354-4664 (print)
dc.identifier.issn1821-4339 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/300
dc.description.abstractSocial isolation induced a significant increase in resting heart rate and reduction in heart rate variability. Dysfunction of the intrinsic cardiac nervous system is implicated in the genesis of cardiovascular diseases. Previous evidence suggests that cardiac ganglia contain noradrenergic neurons. Thus, immunohistochemical expression of catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) and vesicular monoamine transporter 2 (VMAT2) were analyzed, as well as the effects of social isolation stress on mRNA and protein levels of this enzyme and transporter in the intrinsic cardiac nervous system of adult rats. Our results indicate that cardiac ganglion neurons express TH and VMAT2 immunoreactivity. Chronic isolated stress of rats caused a decrease in TH mRNA and VMAT2 mRNA in the neurons of intrinsic cardiac ganglia. No significant alterations in the protein levels of TH and VMAT2 were observed in these neurons. These data indicate that the neurons of intrinsic cardiac ganglia express TH as well as VMAT2 but that social isolation stress does not change their protein levels.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectSocial isolationen
dc.subjectratsen
dc.subjectintrinsic cardiac gangliaen
dc.subjecttyrosine hydroxylaseen
dc.subjectvesicular monoamine transporter 2en
dc.titleImmunohistochemical Detection and Gene Expression of Tyrosine Hydroxylase and Vesicular Monoamine Transporter Type 2 in Intrinsic Cardiac Ganglia of Socially Isolated Ratsen
dc.typearticleen
dcterms.abstractЈовановић Предраг; Спасојевић Наташа; Стефановић Бојана; Дроњак Слађана; Пускас, Нела;
dc.citation.volume66
dc.citation.issue4
dc.citation.spage1645
dc.citation.epage1651
dc.identifier.wos000346477900042
dc.identifier.doi10.2298/ABS1404645J
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84921652042
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12355/296.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record