Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats
Апстракт
Catecholamines in some central (hypothalamus and hippocampus) and peripheral tissues (adrenal glands and heart auricles) of long-term socially isolated normotensive and spontaneously hypertensive rats exposed to novel immobilization stress were determined by a simultaneous single isotope radioenzymatic assay. Long-term isolation (21 days) produced depletion of hypothalamic norepinephrine (NE) stores and hippocampal dopamine (DA) stores in both normotensive and spontaneously hypertensive rats. Acute immobilization stress (2 h) significantly decreased NE and DA stores in hypothalamus and hippocampus of naive normotensive and spontaneously hypertensive rats controls. However, novel immobilization stress applied to normotensive rats previously subjected to long-term isolation produced no changes in catecholamine levels in hypothalamus, while resulting in somewhat higher depletion of NE stores in hypothalamus of spontaneously hypertensive rats treated in the same way. Novel immobilization s...tress decreased NE and DA stores in hippocampus of normotensive but was without effect on NE and DA stores of spontaneously hypertensive rats. Social isolation did not affect catecholamine stores in peripheral tissues but novel immobilization stress produced a significant decrease in catecholamine content. The results suggest that some central and peripherals tissues of spontaneously hypertensive rats and normotensive rats differ with regard to catecholamine content and that there are certain differences in their responsiveness to stress. (c) 2005 Elsevier B.V. All rights reserved.
Кључне речи:
social isolation / hippocampus / hypothalamus / adrenal gland / catecholaminesИзвор:
Autonomic Neuroscience: Basic and Clinical, 2005, 122, 1-2, 38-44
DOI: 10.1016/j.autneu.2005.07.010
ISSN: 1566-0702
PubMed: 16172022
WoS: 000233154800005
Scopus: 2-s2.0-26944463057
Колекције
Институција/група
VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Spasojević, Nataša AU - Dronjak, Slađana PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2945 AB - Catecholamines in some central (hypothalamus and hippocampus) and peripheral tissues (adrenal glands and heart auricles) of long-term socially isolated normotensive and spontaneously hypertensive rats exposed to novel immobilization stress were determined by a simultaneous single isotope radioenzymatic assay. Long-term isolation (21 days) produced depletion of hypothalamic norepinephrine (NE) stores and hippocampal dopamine (DA) stores in both normotensive and spontaneously hypertensive rats. Acute immobilization stress (2 h) significantly decreased NE and DA stores in hypothalamus and hippocampus of naive normotensive and spontaneously hypertensive rats controls. However, novel immobilization stress applied to normotensive rats previously subjected to long-term isolation produced no changes in catecholamine levels in hypothalamus, while resulting in somewhat higher depletion of NE stores in hypothalamus of spontaneously hypertensive rats treated in the same way. Novel immobilization stress decreased NE and DA stores in hippocampus of normotensive but was without effect on NE and DA stores of spontaneously hypertensive rats. Social isolation did not affect catecholamine stores in peripheral tissues but novel immobilization stress produced a significant decrease in catecholamine content. The results suggest that some central and peripherals tissues of spontaneously hypertensive rats and normotensive rats differ with regard to catecholamine content and that there are certain differences in their responsiveness to stress. (c) 2005 Elsevier B.V. All rights reserved. T2 - Autonomic Neuroscience: Basic and Clinical T1 - Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats VL - 122 IS - 1-2 SP - 38 EP - 44 DO - 10.1016/j.autneu.2005.07.010 ER -
@article{ author = "Gavrilović, Ljubica and Spasojević, Nataša and Dronjak, Slađana", year = "2005", abstract = "Catecholamines in some central (hypothalamus and hippocampus) and peripheral tissues (adrenal glands and heart auricles) of long-term socially isolated normotensive and spontaneously hypertensive rats exposed to novel immobilization stress were determined by a simultaneous single isotope radioenzymatic assay. Long-term isolation (21 days) produced depletion of hypothalamic norepinephrine (NE) stores and hippocampal dopamine (DA) stores in both normotensive and spontaneously hypertensive rats. Acute immobilization stress (2 h) significantly decreased NE and DA stores in hypothalamus and hippocampus of naive normotensive and spontaneously hypertensive rats controls. However, novel immobilization stress applied to normotensive rats previously subjected to long-term isolation produced no changes in catecholamine levels in hypothalamus, while resulting in somewhat higher depletion of NE stores in hypothalamus of spontaneously hypertensive rats treated in the same way. Novel immobilization stress decreased NE and DA stores in hippocampus of normotensive but was without effect on NE and DA stores of spontaneously hypertensive rats. Social isolation did not affect catecholamine stores in peripheral tissues but novel immobilization stress produced a significant decrease in catecholamine content. The results suggest that some central and peripherals tissues of spontaneously hypertensive rats and normotensive rats differ with regard to catecholamine content and that there are certain differences in their responsiveness to stress. (c) 2005 Elsevier B.V. All rights reserved.", journal = "Autonomic Neuroscience: Basic and Clinical", title = "Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats", volume = "122", number = "1-2", pages = "38-44", doi = "10.1016/j.autneu.2005.07.010" }
Gavrilović, L., Spasojević, N.,& Dronjak, S.. (2005). Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats. in Autonomic Neuroscience: Basic and Clinical, 122(1-2), 38-44. https://doi.org/10.1016/j.autneu.2005.07.010
Gavrilović L, Spasojević N, Dronjak S. Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats. in Autonomic Neuroscience: Basic and Clinical. 2005;122(1-2):38-44. doi:10.1016/j.autneu.2005.07.010 .
Gavrilović, Ljubica, Spasojević, Nataša, Dronjak, Slađana, "Novel stressors affected catecholamine stores in socially isolated normotensive and spontaneously hypertensive rats" in Autonomic Neuroscience: Basic and Clinical, 122, no. 1-2 (2005):38-44, https://doi.org/10.1016/j.autneu.2005.07.010 . .