Mathematical modeling of the hypothalamic-pituitary-adrenal system activity
Апстракт
Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pitutary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet. (c) 2005 Elsevier Inc. All rights reserved.
Кључне речи:
HPA system / cortisol / mathematical model / non-linear dynamics / stability analysisИзвор:
Mathematical Biosciences, 2005, 197, 2, 173-187
DOI: 10.1016/j.mbs.2005.06.006
ISSN: 0025-5564
PubMed: 16112688
WoS: 000232976200004
Scopus: 2-s2.0-25844487749
Колекције
Институција/група
VinčaTY - JOUR AU - Jelić, Smiljana AU - Cupic, Z AU - Kolar-Anic, L PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2943 AB - Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pitutary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet. (c) 2005 Elsevier Inc. All rights reserved. T2 - Mathematical Biosciences T1 - Mathematical modeling of the hypothalamic-pituitary-adrenal system activity VL - 197 IS - 2 SP - 173 EP - 187 DO - 10.1016/j.mbs.2005.06.006 ER -
@article{ author = "Jelić, Smiljana and Cupic, Z and Kolar-Anic, L", year = "2005", abstract = "Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pitutary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet. (c) 2005 Elsevier Inc. All rights reserved.", journal = "Mathematical Biosciences", title = "Mathematical modeling of the hypothalamic-pituitary-adrenal system activity", volume = "197", number = "2", pages = "173-187", doi = "10.1016/j.mbs.2005.06.006" }
Jelić, S., Cupic, Z.,& Kolar-Anic, L.. (2005). Mathematical modeling of the hypothalamic-pituitary-adrenal system activity. in Mathematical Biosciences, 197(2), 173-187. https://doi.org/10.1016/j.mbs.2005.06.006
Jelić S, Cupic Z, Kolar-Anic L. Mathematical modeling of the hypothalamic-pituitary-adrenal system activity. in Mathematical Biosciences. 2005;197(2):173-187. doi:10.1016/j.mbs.2005.06.006 .
Jelić, Smiljana, Cupic, Z, Kolar-Anic, L, "Mathematical modeling of the hypothalamic-pituitary-adrenal system activity" in Mathematical Biosciences, 197, no. 2 (2005):173-187, https://doi.org/10.1016/j.mbs.2005.06.006 . .