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Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
dc.creator | Čudina, Olivera | |
dc.creator | Čomor, Mirjana | |
dc.creator | Janković, Ivana A. | |
dc.date.accessioned | 2018-03-01T19:37:21Z | |
dc.date.available | 2018-03-01T19:37:21Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2880 | |
dc.description.abstract | A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, used as preservative, in pharmaceutical formulations. Method employed Zorbax Eclipse XDB-C18 (250x4.6 mm i.d., 5 mu m) column, methanol-ammonium acetate (pH 2; 65 mM) (65:35, v/v, pH(*) 3.6) as mobile phase with flow rate of 1 mL min(-1) and variable UV detection at 220 and 252 nm. The proposed method was validated by testing its linearity, selectivity, recovery, repeatability, LOD/LOQ values and it was successfully employed for the determination of bifonazole and benzyl alcohol in pharmaceutical cream-based formulations. | en |
dc.rights | restrictedAccess | en |
dc.source | Chromatographia | en |
dc.subject | column liquid chromatography | en |
dc.subject | pharmaceutical formulations | en |
dc.subject | benzyl alcohol | en |
dc.subject | bifonazole | en |
dc.title | Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC | en |
dc.type | article | en |
dcterms.abstract | Јанковиц, ИA; Цудина, ОA; Чомор Мирјана; | |
dc.citation.volume | 61 | |
dc.citation.issue | 7-8 | |
dc.citation.spage | 415 | |
dc.citation.epage | 418 | |
dc.identifier.wos | 000228610300019 | |
dc.identifier.doi | 10.1365/s10337-005-0524-9 | |
dc.citation.rank | M23 | |
dc.identifier.scopus | 2-s2.0-17644393561 |
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