Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide
Apstrakt
In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(...4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.
Ključne reči:
hydrochlorothiazide / CTAB / micelles / binding constant / partition coefficientIzvor:
Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 2005, 256, 2-3, 225-232
DOI: 10.1016/j.colsurfa.2005.01.023
ISSN: 0927-7757
WoS: 000228322800018
Scopus: 2-s2.0-14844300859
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Čudina, Olivera AU - Karljiković-Rajić, Katarina AU - Ruvarac-Bugarčić, Ivanka A. AU - Janković, Ivana A. PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2878 AB - In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved. T2 - Colloids and Surfaces. A: Physicochemical and Engineering Aspects T1 - Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide VL - 256 IS - 2-3 SP - 225 EP - 232 DO - 10.1016/j.colsurfa.2005.01.023 ER -
@article{ author = "Čudina, Olivera and Karljiković-Rajić, Katarina and Ruvarac-Bugarčić, Ivanka A. and Janković, Ivana A.", year = "2005", abstract = "In this study, the interaction of hydrochlorothiazide (HCT), benzothiadiazine diuretic, with cationic surfactant cetyltrimethylammonium bromide (CTAB) was investigated. The effect of cationic micelles on the spectroscopic and acid-base properties of HCT was studied at pH 10.5. The binding of HCT to CTAB micelles implied a shift in drug acidity constant (pK(a)(water) - pK(a)(micelle) =0.46) proving the greater affinity of HCT dianion for the positively charged CTAB micelle surface. From the dependence of differential absorbance at lambda = 355 nm on CTAB concentration, by using mathematical model that treats the solubilization of HCT dianion as its binding to specific sites in the micelles (Langmuir adsorption isotherm), the binding constant K-b = (1.17 +/- 0.16) x 10(4) mol(-1) dm(3) was obtained. By using pseudo-phase model, the partition coefficient between the bulk water and CTAB micelles, K-x, was calculated from both differential absorbance Delta A(355), K-x =(6.18 +/- 0.64) x 10(4) mol((1) dm(3), and first-order derivative amplitude D-1(250.1), K-x =(5.47 +/- 0.56) x 10(4) mol((1) dm(3). (c) 2005 Elsevier B.V. All rights reserved.", journal = "Colloids and Surfaces. A: Physicochemical and Engineering Aspects", title = "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide", volume = "256", number = "2-3", pages = "225-232", doi = "10.1016/j.colsurfa.2005.01.023" }
Čudina, O., Karljiković-Rajić, K., Ruvarac-Bugarčić, I. A.,& Janković, I. A.. (2005). Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256(2-3), 225-232. https://doi.org/10.1016/j.colsurfa.2005.01.023
Čudina O, Karljiković-Rajić K, Ruvarac-Bugarčić IA, Janković IA. Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide. in Colloids and Surfaces. A: Physicochemical and Engineering Aspects. 2005;256(2-3):225-232. doi:10.1016/j.colsurfa.2005.01.023 .
Čudina, Olivera, Karljiković-Rajić, Katarina, Ruvarac-Bugarčić, Ivanka A., Janković, Ivana A., "Interaction of hydrochlorothiazide with cationic surfactant micelles of cetyltrimethylammonium bromide" in Colloids and Surfaces. A: Physicochemical and Engineering Aspects, 256, no. 2-3 (2005):225-232, https://doi.org/10.1016/j.colsurfa.2005.01.023 . .