Show simple item record

dc.creatorPejić, Snežana
dc.creatorKasapović, Jelena
dc.creatorCvetkovic, D
dc.creatorPajović, Snežana B.
dc.date.accessioned2018-03-01T19:16:26Z
dc.date.available2018-03-01T19:16:26Z
dc.date.issued2003
dc.identifier.issn0100-879X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2634
dc.description.abstractThe sensitivity of copper,zinc (CuZn)- and manganese (Mn)-superoxide dismutase (SOD) to exogenous estradiol benzoate (EB) was investigated in Wistar rats during postnatal brain development. Enzyme activities were measured in samples prepared from brains of rats of both sexes and various ages between 0 and 75 days, treated sc with 0.5 mug EB/100 g body weight in 0.1 ml olive oil/100 g body weight, 48 and 24 h before sacrifice. In females, EB treatment stimulated MnSOD activity on days 0 (66.1%), 8 (72.7%) and 15 (81.7%). In males, the stimulatory effect of EB on MnSOD activity on day 0 (113.6%) disappeared on day 8 and on days 15. and 45 it became inhibitory (40.3 and 30.5%, respectively). EB had no effect on the other age groups. The stimulatory effect of EB on CuZnSOD activity in newborn females (51.8%) changed to an inhibitory effect on day 8 (38.4%) and disappeared by day 45 when inhibition was detected again (48.7%). In males, the inhibitory effect on this enzyme was observed on days 0 (45.0%) and 15 (28.9%), and then disappeared until day 60 when a stimulatory effect was observed (38.4%). EB treatment had no effect on the other age groups. The sensitivity of MnSOD to estradiol differed significantly between sexes during the neonatal and prepubertal period, whereas it followed a similar pattern thereafter. The sensitivity of CuZnSOD to estradiol differed significantly between sexes during most of the study period. Regression analysis showed that the sensitivity of MnSOD to this estrogen tended to decrease similarly in both sexes, whereas the sensitivity of CuZnSOD showed a significantly different opposite tendency in female and male rats. These are the first reports indicating hormonal modulation of antioxidant enzyme activities related to the developmental process.en
dc.rightsopenAccessen
dc.sourceBrazilian Journal of Medical and Biological Researchen
dc.subjectbrainen
dc.subjectbrain developmenten
dc.subjectestradiolen
dc.subjectsuperoxide dismutaseen
dc.titleThe modulatory effect of estradiol benzoate on superoxide dismutase activity in the developing rat brainen
dc.typearticleen
dcterms.abstractЦветковиц, Д; Пајовиц, СБ; Пејић Снежана; Касаповић Јелена;
dc.citation.volume36
dc.citation.issue5
dc.citation.spage579
dc.citation.epage586
dc.identifier.wos000183100000004
dc.identifier.doi10.1590/S0100-879X2003000500004
dc.citation.rankM23
dc.identifier.pmid12715076
dc.identifier.scopus2-s2.0-0038279744
dc.identifier.fulltexthttp://vinar.rcub.bg.ac.rs/bitstream/handle/123456789/2634/4718.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record