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dc.creatorArandjelovic, S
dc.creatorTešić, Živoslav
dc.creatorJuranic, Z
dc.creatorRadulović, Siniša S.
dc.creatorVrvic, M
dc.creatorPotkonjak, Branislav
dc.creatorIlic, Z
dc.date.accessioned2018-03-01T19:14:17Z
dc.date.available2018-03-01T19:14:17Z
dc.date.issued2002
dc.identifier.issn0392-9078 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2609
dc.description.abstractPurpose of this work was to synthesize several cis-/trans- isomer pairs of the platinum(II) complexes, and study the extent and the mode of their antiproliferative activity on HeLa cells. Six platinum(II) isomer pairs have a general formula cis-/trans-[PtA(2) X-2] where A is ligand: ammonia (NH3), pyridine (Py); and X is ligand: chloride ion (Cl-), bromide ion (Br-), iodide ion (I-), thiocyanato, ion (SCN-); four compounds have different structural formulas, and these are cis-/trans-[Pt(NH2OH)(2) (NH3)(2)]Cl-2, and cis-/trans- Pt(Gly)(2), where Gly is bidentate glycinato ligand. Results of the MTT assay, showed that six cis- and one trans-platinum(II) complexes exhibited cytotoxicity (IC50) ranging between 5 and 33 muM. Most of the cis-platinum(II) isomers caused significant alteration of cell cycle phases progression, and induced apoptosis in degree that varied among different compounds, as evaluated using flowcytometry and morphological study. Spectrophotometric analysis (AAS) indicated that there is no correlation between intracellular platinum(II) accumulation and cytotoxicity of tested complexes.en
dc.rightsrestrictedAccessen
dc.sourceJournal of Experimental and Clinical Cancer Researchen
dc.subjectcisplatinen
dc.subjectplatinum(II) complexesen
dc.subjectMTTen
dc.subjectapoptosisen
dc.subjectHeLaen
dc.titleAntiproliferative activity of some cis-/trans-platinum(II) complexes on HeLa cellsen
dc.typearticleen
dcterms.abstractAрандјеловиц, С; Јураниц, З; Радуловиц, С; Поткоњак, Б; Илиц, З; Тесиц, З; Врвиц, М;
dc.citation.volume21
dc.citation.issue4
dc.citation.spage519
dc.citation.epage526
dc.identifier.wos000181083800010
dc.citation.rankM23
dc.identifier.pmid12636098


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