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Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors
dc.creator | Gavrilović, Ljubica | |
dc.creator | Dronjak, Slađana | |
dc.date.accessioned | 2018-03-01T19:10:16Z | |
dc.date.available | 2018-03-01T19:10:16Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0172-780X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2564 | |
dc.description.abstract | OBJECTIVE: The effects of three different long-term (21 days) stresses: isolation (LTI), forced swimming (LTS) and isolation accompanied by forced swimming (LTI+LTS) on the level of plasma noradrenaline (NA), adrenaline (A), corticosterone (CORT) and adrenocorticotropic hormone (ACTH), both under basal conditions and in response to short-term immobilization and cold as heterotypic additional stressors, were compared. METHODS: Plasma NA and A were assayed by the radioenzymatic method. Plasma CORT was measured using RIA kits. Plasma ACTH was determined by chemiluminescent method. RESULTS: LTI produced a significant elevation of basal plasma CORT and ACTH, while basal plasma NA and A concentrations remained unchanged. Combination of long-term isolation and forced swimming, produced a significant elevation of basal plasma ACTH content only, while LTS did not influence the basal level of this hormone. When LTI rats were exposed to immobilization and cold, a significant elevation of plasma NA and A level was recorded. In LTS and LTI+LTS groups of rats exposed to immobilization or cold, increased plasma NA and A levels were observed, but this increase was lower in comparison with that found in LTI rats. No difference in plasma CORT content between the three long-term stressed groups of animals was observed, while plasma ACTH level was significantly more elevated in LTS and LTI+LTS than in LTI rats. CONCLUSION: Based on these results, it may be concluded that LTI as a psychosocial stress represents a stronger stressor than LTS. Also, daily short-term (15 min, 21 days) swimming stress seems to attenuate the effect of long-term isolation on the activity of sympatho-adrenomedullary system. | en |
dc.rights | restrictedAccess | en |
dc.source | Neuroendocrinology Letters | en |
dc.subject | long-term stress | en |
dc.subject | CORT | en |
dc.subject | ACTH | en |
dc.subject | catecholamines | en |
dc.subject | isolation | en |
dc.subject | forced swimming | en |
dc.subject | immobilization | en |
dc.subject | cold | en |
dc.title | Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors | en |
dc.type | article | en |
dcterms.abstract | Гавриловић Љубица; Дроњак Слађана; | |
dc.citation.volume | 26 | |
dc.citation.issue | 5 | |
dc.citation.spage | 515 | |
dc.citation.epage | 520 | |
dc.identifier.wos | 000234612300014 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 16264408 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_2564 |
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