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dc.creatorGavrilović, Ljubica
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T19:10:16Z
dc.date.available2018-03-01T19:10:16Z
dc.date.issued2005
dc.identifier.issn0172-780X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2564
dc.description.abstractOBJECTIVE: The effects of three different long-term (21 days) stresses: isolation (LTI), forced swimming (LTS) and isolation accompanied by forced swimming (LTI+LTS) on the level of plasma noradrenaline (NA), adrenaline (A), corticosterone (CORT) and adrenocorticotropic hormone (ACTH), both under basal conditions and in response to short-term immobilization and cold as heterotypic additional stressors, were compared. METHODS: Plasma NA and A were assayed by the radioenzymatic method. Plasma CORT was measured using RIA kits. Plasma ACTH was determined by chemiluminescent method. RESULTS: LTI produced a significant elevation of basal plasma CORT and ACTH, while basal plasma NA and A concentrations remained unchanged. Combination of long-term isolation and forced swimming, produced a significant elevation of basal plasma ACTH content only, while LTS did not influence the basal level of this hormone. When LTI rats were exposed to immobilization and cold, a significant elevation of plasma NA and A level was recorded. In LTS and LTI+LTS groups of rats exposed to immobilization or cold, increased plasma NA and A levels were observed, but this increase was lower in comparison with that found in LTI rats. No difference in plasma CORT content between the three long-term stressed groups of animals was observed, while plasma ACTH level was significantly more elevated in LTS and LTI+LTS than in LTI rats. CONCLUSION: Based on these results, it may be concluded that LTI as a psychosocial stress represents a stronger stressor than LTS. Also, daily short-term (15 min, 21 days) swimming stress seems to attenuate the effect of long-term isolation on the activity of sympatho-adrenomedullary system.en
dc.rightsrestrictedAccessen
dc.sourceNeuroendocrinology Lettersen
dc.subjectlong-term stressen
dc.subjectCORTen
dc.subjectACTHen
dc.subjectcatecholaminesen
dc.subjectisolationen
dc.subjectforced swimmingen
dc.subjectimmobilizationen
dc.subjectcolden
dc.titleActivation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressorsen
dc.typearticleen
dcterms.abstractГавриловић Љубица; Дроњак Слађана;
dc.citation.volume26
dc.citation.issue5
dc.citation.spage515
dc.citation.epage520
dc.identifier.wos000234612300014
dc.citation.rankM23
dc.identifier.pmid16264408


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