Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors
Апстракт
OBJECTIVE: The effects of three different long-term (21 days) stresses: isolation (LTI), forced swimming (LTS) and isolation accompanied by forced swimming (LTI+LTS) on the level of plasma noradrenaline (NA), adrenaline (A), corticosterone (CORT) and adrenocorticotropic hormone (ACTH), both under basal conditions and in response to short-term immobilization and cold as heterotypic additional stressors, were compared. METHODS: Plasma NA and A were assayed by the radioenzymatic method. Plasma CORT was measured using RIA kits. Plasma ACTH was determined by chemiluminescent method. RESULTS: LTI produced a significant elevation of basal plasma CORT and ACTH, while basal plasma NA and A concentrations remained unchanged. Combination of long-term isolation and forced swimming, produced a significant elevation of basal plasma ACTH content only, while LTS did not influence the basal level of this hormone. When LTI rats were exposed to immobilization and cold, a significant elevation of plasma N...A and A level was recorded. In LTS and LTI+LTS groups of rats exposed to immobilization or cold, increased plasma NA and A levels were observed, but this increase was lower in comparison with that found in LTI rats. No difference in plasma CORT content between the three long-term stressed groups of animals was observed, while plasma ACTH level was significantly more elevated in LTS and LTI+LTS than in LTI rats. CONCLUSION: Based on these results, it may be concluded that LTI as a psychosocial stress represents a stronger stressor than LTS. Also, daily short-term (15 min, 21 days) swimming stress seems to attenuate the effect of long-term isolation on the activity of sympatho-adrenomedullary system.
Кључне речи:
long-term stress / CORT / ACTH / catecholamines / isolation / forced swimming / immobilization / coldИзвор:
Neuroendocrinology Letters, 2005, 26, 5, 515-520Колекције
Институција/група
VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Dronjak, Slađana PY - 2005 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2564 AB - OBJECTIVE: The effects of three different long-term (21 days) stresses: isolation (LTI), forced swimming (LTS) and isolation accompanied by forced swimming (LTI+LTS) on the level of plasma noradrenaline (NA), adrenaline (A), corticosterone (CORT) and adrenocorticotropic hormone (ACTH), both under basal conditions and in response to short-term immobilization and cold as heterotypic additional stressors, were compared. METHODS: Plasma NA and A were assayed by the radioenzymatic method. Plasma CORT was measured using RIA kits. Plasma ACTH was determined by chemiluminescent method. RESULTS: LTI produced a significant elevation of basal plasma CORT and ACTH, while basal plasma NA and A concentrations remained unchanged. Combination of long-term isolation and forced swimming, produced a significant elevation of basal plasma ACTH content only, while LTS did not influence the basal level of this hormone. When LTI rats were exposed to immobilization and cold, a significant elevation of plasma NA and A level was recorded. In LTS and LTI+LTS groups of rats exposed to immobilization or cold, increased plasma NA and A levels were observed, but this increase was lower in comparison with that found in LTI rats. No difference in plasma CORT content between the three long-term stressed groups of animals was observed, while plasma ACTH level was significantly more elevated in LTS and LTI+LTS than in LTI rats. CONCLUSION: Based on these results, it may be concluded that LTI as a psychosocial stress represents a stronger stressor than LTS. Also, daily short-term (15 min, 21 days) swimming stress seems to attenuate the effect of long-term isolation on the activity of sympatho-adrenomedullary system. T2 - Neuroendocrinology Letters T1 - Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors VL - 26 IS - 5 SP - 515 EP - 520 UR - https://hdl.handle.net/21.15107/rcub_vinar_2564 ER -
@article{ author = "Gavrilović, Ljubica and Dronjak, Slađana", year = "2005", abstract = "OBJECTIVE: The effects of three different long-term (21 days) stresses: isolation (LTI), forced swimming (LTS) and isolation accompanied by forced swimming (LTI+LTS) on the level of plasma noradrenaline (NA), adrenaline (A), corticosterone (CORT) and adrenocorticotropic hormone (ACTH), both under basal conditions and in response to short-term immobilization and cold as heterotypic additional stressors, were compared. METHODS: Plasma NA and A were assayed by the radioenzymatic method. Plasma CORT was measured using RIA kits. Plasma ACTH was determined by chemiluminescent method. RESULTS: LTI produced a significant elevation of basal plasma CORT and ACTH, while basal plasma NA and A concentrations remained unchanged. Combination of long-term isolation and forced swimming, produced a significant elevation of basal plasma ACTH content only, while LTS did not influence the basal level of this hormone. When LTI rats were exposed to immobilization and cold, a significant elevation of plasma NA and A level was recorded. In LTS and LTI+LTS groups of rats exposed to immobilization or cold, increased plasma NA and A levels were observed, but this increase was lower in comparison with that found in LTI rats. No difference in plasma CORT content between the three long-term stressed groups of animals was observed, while plasma ACTH level was significantly more elevated in LTS and LTI+LTS than in LTI rats. CONCLUSION: Based on these results, it may be concluded that LTI as a psychosocial stress represents a stronger stressor than LTS. Also, daily short-term (15 min, 21 days) swimming stress seems to attenuate the effect of long-term isolation on the activity of sympatho-adrenomedullary system.", journal = "Neuroendocrinology Letters", title = "Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors", volume = "26", number = "5", pages = "515-520", url = "https://hdl.handle.net/21.15107/rcub_vinar_2564" }
Gavrilović, L.,& Dronjak, S.. (2005). Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors. in Neuroendocrinology Letters, 26(5), 515-520. https://hdl.handle.net/21.15107/rcub_vinar_2564
Gavrilović L, Dronjak S. Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors. in Neuroendocrinology Letters. 2005;26(5):515-520. https://hdl.handle.net/21.15107/rcub_vinar_2564 .
Gavrilović, Ljubica, Dronjak, Slađana, "Activation of rat pituitary-adrenocortical and sympatho-adrenomedullary system in response to different stressors" in Neuroendocrinology Letters, 26, no. 5 (2005):515-520, https://hdl.handle.net/21.15107/rcub_vinar_2564 .