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Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy
dc.creator | Fani, M | |
dc.creator | Vranješ, Sanja | |
dc.creator | Archimandritis, Spyridon | |
dc.creator | Potamianos, S | |
dc.creator | Xanthopoulos, S | |
dc.creator | Bouziotis, Penelope | |
dc.creator | Varvarigou, AD | |
dc.date.accessioned | 2018-03-01T19:09:38Z | |
dc.date.available | 2018-03-01T19:09:38Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0969-8043 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2557 | |
dc.description.abstract | The labeling of a monoclonal (anti-CEA) and a polyclonal (IgG) antibody with Sm-153 has been investigated, using the bicyclic anhydride of DTPA (cDTPAa) as the chelating agent. The radiochemical study was performed using a combination of radioanalytical techniques (gel filtration, HPLC, ITLC-SG and SDS-PAGE). Optimization of factors affecting labeling (pH, Ab, Ab-DTPA concentration, etc.) leads to a labeling yield higher than 90%. Biodistribution studies in normal mice showed slow blood clearance and high uptake into the liver, kidney and lungs. (C) 2002 Elsevier Science Ltd. All rights reserved. | en |
dc.rights | restrictedAccess | en |
dc.source | Applied Radiation and Isotopes | en |
dc.subject | Sm-153 | en |
dc.subject | radiolabeled antibody | en |
dc.subject | radiochemical study | en |
dc.subject | radioimmunotherapy | en |
dc.title | Labeling of monoclonal antibodies with Sm-153 for potential use in radioimmunotherapy | en |
dc.type | article | en |
dcterms.abstract | Фани, М; Врањес, С; Xантхопоулос, С; Боузиотис, П; Варваригоу, AД; Aрцхимандритис, СЦ; Потамианос, С; | |
dc.citation.volume | 57 | |
dc.citation.issue | 5 | |
dc.citation.spage | 665 | |
dc.citation.epage | 674 | |
dc.identifier.wos | 000178847900009 | |
dc.identifier.doi | 10.1016/S0969-8043(02)00181-1 | |
dc.citation.other | Article Number: PII S0969-8043(02)00181-1 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 12433040 | |
dc.identifier.scopus | 2-s2.0-0036844250 |
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