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dc.creatorPopsavin, M
dc.creatorTorovic, L
dc.creatorSpaic, S
dc.creatorStankov, S
dc.creatorKapor, A
dc.creatorTomić, Zoran D.
dc.creatorPopsavin, V
dc.date.accessioned2018-03-01T19:04:02Z
dc.date.available2018-03-01T19:04:02Z
dc.date.issued2002
dc.identifier.issn0040-4020 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2494
dc.description.abstract3(5)-Carboxamido-4-(beta-D-ribofuranosyl)pyrazoles bearing 2-benzamido (15) and 3-mesyloxy (29) isosteric groups, as well as the tetrazole C-nucleosides with 2-benzamido-2-deoxy-beta-D-ribofuranose (19) and 3-azido-3-deoxy-beta-D-xylofuranose (36) as sugar segments, have been synthesized starting from D-glucose, by utilizing the 2,5-anhydro-D-glucose ethylene acetal derivatives 1 and 20 as divergent intermediates. The C-nucleosides 15 and 36 were shown to be moderate inhibitors of the in vitro growth of both N2a and BHK 21 tumour cell lines, whereas 29 showed a selective, although not potent cytotoxic activity against N2a cells. Compound 29 also showed a moderate in vitro antiviral activity towards the rabies virus. (C) 2002 Elsevier Science Ltd. All rights reserved.en
dc.rightsrestrictedAccessen
dc.sourceTetrahedronen
dc.subjectC-nucleosidesen
dc.subjectpyrazolesen
dc.subjecttetrazolesen
dc.subjectcytotoxic activityen
dc.subjectantiviral activityen
dc.subject2,5-anhydro sugarsen
dc.subjectX-ray crystallographyen
dc.titleSynthesis and biological evaluation of new pyrazole- and tetrazole-related C-nucleosides with modified sugar moietiesen
dc.typearticleen
dcterms.abstractТоровиц, Л; Спаиц, С; Станков, С; Капор, A; Попсавин, М; Томић Зоран; Попсавин, В;
dc.citation.volume58
dc.citation.issue3
dc.citation.spage569
dc.citation.epage580
dc.identifier.wos000173338300012
dc.identifier.doi10.1016/S0040-4020(01)01126-7
dc.citation.rankM21
dc.identifier.scopus2-s2.0-0037074195


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