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dc.creatorBanjac, A
dc.creatorNedeljkovic, N
dc.creatorHorvat, Anica
dc.creatorKanazir, D
dc.creatorNikezic, G
dc.date.accessioned2018-03-01T19:00:35Z
dc.date.available2018-03-01T19:00:35Z
dc.date.issued2001
dc.identifier.issn0862-8408 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2455
dc.description.abstractAn ontogenetic study of ecto-ATPase activity and the content of enzyme proteins was assessed in the caudate nucleus and hippocampal synaptic plasma membranes isolated from rats at various ages (15, 30, 90, 180 and 365 days). The ontogenetic profile revealed that the enzyme activities in both brain areas were the highest on day 30 and 365, while the ecto-ATPase protein abundance was the highest on day 15 after birth. Possible explanation for obtained ontogenetic profile and the discrepancy between activity and abundance may reside in the fact that ecto-ATPase during development could exert additional roles other than those related to metabolism of ATP. It is likely that ecto-ATPase, regulating the concentration of ATP and adenosine in synaptic cleft, has important role in the processes of brain development and aging.en
dc.rightsrestrictedAccessen
dc.sourcePhysiological Researchen
dc.subjectecto-ATPaseen
dc.subjectextracellular purinesen
dc.subjectdevelopmenten
dc.subjectagingen
dc.subjectbrainen
dc.titleOntogenetic profile of ecto-ATPase activity in rat hippocampal and caudate nucleus synaptic plasma membrane fractionsen
dc.typearticleen
dcterms.abstractБањац, A; Недељковиц, Н; Каназир, Д; Никезиц, Г; Хорват, Aница;
dc.citation.volume50
dc.citation.issue4
dc.citation.spage411
dc.citation.epage417
dc.identifier.wos000170782700011
dc.citation.rankM23
dc.identifier.pmid11551148


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