Show simple item record

dc.creatorSevaljevic, L
dc.creatorIsenović, Esma R.
dc.creatorVulović, Mojica
dc.creatorMacvanin, M
dc.creatorŽakula, Zorica
dc.creatorKanazir, D
dc.creatorRibarac-Stepić, Nevena B.
dc.date.accessioned2018-03-01T19:00:08Z
dc.date.available2018-03-01T19:00:08Z
dc.date.issued2001
dc.identifier.issn1422-4933 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2450
dc.description.abstractThe responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.en
dc.rightsrestrictedAccessen
dc.sourceBiological Signals and Receptorsen
dc.subjectsteroidsen
dc.subjectacute-phase cytokinesen
dc.subjectglucocorticoid receptorsen
dc.subjecttyrosine aminotransferaseen
dc.subjectalpha(2)-macroglobulinen
dc.subjectgamma-fibrinogenen
dc.subjectsignal transductionen
dc.titleThe responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokinesen
dc.typearticleen
dcterms.abstractСеваљевиц, Л; Закула, З; Каназир, Д; Рибарац-Степиц, Н; Вуловиц, М; Мацванин, М; Исеновић Есма;
dc.citation.volume10
dc.citation.issue5
dc.citation.spage299
dc.citation.epage309
dc.identifier.wos000170516300003
dc.citation.rankM22
dc.identifier.pmid11490095


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record