The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines
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Sevaljevic, LIsenović, Esma R.
Vulović, Mojca D.
Mačvanin, Mirjana
Žakula, Zorica
Kanazir, Dušan T.
Ribarac-Stepić, Nevena B.
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The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR bi...nding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.
Keywords:
steroids / acute-phase cytokines / glucocorticoid receptors / tyrosine aminotransferase / alpha(2)-macroglobulin / gamma-fibrinogen / signal transductionSource:
Biological Signals and Receptors, 2001, 10, 5, 299-309Collections
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VinčaTY - JOUR AU - Sevaljevic, L AU - Isenović, Esma R. AU - Vulović, Mojca D. AU - Mačvanin, Mirjana AU - Žakula, Zorica AU - Kanazir, Dušan T. AU - Ribarac-Stepić, Nevena B. PY - 2001 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2450 AB - The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes. T2 - Biological Signals and Receptors T1 - The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines VL - 10 IS - 5 SP - 299 EP - 309 UR - https://hdl.handle.net/21.15107/rcub_vinar_2450 ER -
@article{ author = "Sevaljevic, L and Isenović, Esma R. and Vulović, Mojca D. and Mačvanin, Mirjana and Žakula, Zorica and Kanazir, Dušan T. and Ribarac-Stepić, Nevena B.", year = "2001", abstract = "The responses of liver glucocorticoid receptor (GR) and genes coding for a glucocorticoid-inducible tyrosine aminotransferase (TAT) and two acute-phase proteins (APP) [alpha (2)-macroglobulin (alpha (2)-M) and gamma -fibrinogen (Fb)] to changes in glucocorticoid (GC) and proinflammatory (AP) cytokine contents have been examined in rats after single or combined treatments with turpentine oil, dexamethasone (Dex) and adrenalectomy. Activation of two APP genes in turpentine-induced inflammation was accompanied by an increase in the level of GR mRNA and a preferential translocation of GR-GC complexes to the nucleoplasm, while the expression of TAT remained unaltered. Dex alone caused a decrease in the levels of GR and Fb mRNAs, activation of TAT and alpha (2)-M genes, a decrease in the affinity of hormone binding sites and redistribution of translocated GR-Dex complexes within the nuclei. Inflammation potentiated the effect which Dex alone exerted on the GIR content and the number of GR binding sites but counteracted its influence on the affinity of GR binding sites and nuclear distribution of GR-Dex complexes.", journal = "Biological Signals and Receptors", title = "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines", volume = "10", number = "5", pages = "299-309", url = "https://hdl.handle.net/21.15107/rcub_vinar_2450" }
Sevaljevic, L., Isenović, E. R., Vulović, M. D., Mačvanin, M., Žakula, Z., Kanazir, D. T.,& Ribarac-Stepić, N. B.. (2001). The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors, 10(5), 299-309. https://hdl.handle.net/21.15107/rcub_vinar_2450
Sevaljevic L, Isenović ER, Vulović MD, Mačvanin M, Žakula Z, Kanazir DT, Ribarac-Stepić NB. The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines. in Biological Signals and Receptors. 2001;10(5):299-309. https://hdl.handle.net/21.15107/rcub_vinar_2450 .
Sevaljevic, L, Isenović, Esma R., Vulović, Mojca D., Mačvanin, Mirjana, Žakula, Zorica, Kanazir, Dušan T., Ribarac-Stepić, Nevena B., "The responses of rat liver glucocorticoid receptors and genes for tyrosine aminotransferase, alpha-2-macroglobulin and gamma-fibrinogen to adrenalectomy-, dexamethasone- and inflammation-induced changes in the levels of glucocorticoids and proinflammatory cytokines" in Biological Signals and Receptors, 10, no. 5 (2001):299-309, https://hdl.handle.net/21.15107/rcub_vinar_2450 .