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Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure
dc.creator | Radojčić, Marija | |
dc.creator | Crompton, NEA | |
dc.date.accessioned | 2018-03-01T18:59:36Z | |
dc.date.available | 2018-03-01T18:59:36Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0301-634X | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/2444 | |
dc.description.abstract | Peripheral blood samples from three donors of different ages were exposed to 300 kVp x-rays or 138 MeV protons (0, 2, and 9 Gy dose). After 48 h incubation, CD4 and CD8 T-lymphocytes were labelled with specific monoclonal antibodies and cellular DNA was stained by propidium iodine. Radiation-induced apoptosis was followed by flow cytometry and the data were processed by LYSIS II software. The data analysis revealed an age-dependent sensitivity to radiation-induced apoptosis by 300 kVp x-rays and 138 MeV protons, for both CD4 and CD8 T-lymphocytes. Radiation-induced apoptosis was about 4 times greater in CD4 lymphocytes from the youngest donor than the oldest donor and was about 2 times greater in CD8 T-lymphocytes, both after x-ray and proton exposures. RBE values for CD4 T-lymphocytes ranged from 0.9 to 1.4 and for CD8-positive cells from 0.7 to 0.9. It is concluded that radiation-induced apoptosis of CD4 and CD8 T-lymphocytes, which is already exploited to pi-edict patient response in conventional radiotherapy, may also be used to predict response in proton treatment planning. | en |
dc.rights | restrictedAccess | en |
dc.source | Radiation and Environmental Biophysics | en |
dc.title | Age dependence of T-lymphocyte apoptosis induced by high-energy proton exposure | en |
dc.type | article | en |
dcterms.abstract | Радојциц, М; Цромптон, НЕA; | |
dc.citation.volume | 40 | |
dc.citation.issue | 2 | |
dc.citation.spage | 131 | |
dc.citation.epage | 135 | |
dc.identifier.wos | 000169757500005 | |
dc.identifier.doi | 10.1007/s004110100093 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 11484784 | |
dc.identifier.scopus | 2-s2.0-0034958764 |
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