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dc.creatorIvanovic, V
dc.creatorTodorovic-Rakovic, N
dc.creatorDemajo, M
dc.creatorNeskovic-Konstantinovic, Z
dc.creatorNikolic-Vukosavljevic, D
dc.creatorIvanisevic-Milovanovic, O
dc.creatorMitrovic, L
dc.date.accessioned2018-03-01T18:59:05Z
dc.date.available2018-03-01T18:59:05Z
dc.date.issued2001
dc.identifier.issn0354-3447 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2438
dc.description.abstractThere has been much controversy concerning the detection of plasma TGF-beta (1) levels in breast cancer patients. The present study provides preliminary evidence on underestimated plasma TGF-beta (1) levels due to ex vivo proteolysis and previous therapeutic treatment of breast cancer patients, as detected by a commercial ELISA immunoassay. Our results revealed that the addition of protease inhibitors: phenylmethylsulfonyl fluoride and aprotinin, to the plasma preparation of healthy volunteers, has increased TGF-beta (1) median Value from 3.1 ng/mL to 33.9 ng/mL. Relative to that, in protease-inhibited plasma of locally advanced/metastatic breast cancer patients, significantly elevated TGF-beta (1) was observed (median value: 65.5 ng/mL), which included untreated and previously treated patients with median values of: 74.2 ng/mL and 58.1 ng/mL, respectively. These findings indicate to the potential usefulness of this plasma marker in breast cancer prognosis, thus deserving future clinical attention.en
dc.rightsrestrictedAccessen
dc.sourceJugoslovenska Medicinska Biohemijaen
dc.subjectTGF-beta(1)en
dc.subjectplasma biomarkersen
dc.subjectprotease inhibitorsen
dc.subjectbreast canceren
dc.titleDetection of transforming growth factor-beta 1 in human plasma - A pilot study on breast cancer patientsen
dc.typearticleen
dcterms.abstractИвановиц, В; Тодоровиц-Раковиц, Н; Демајо, М; Иванисевиц-Миловановиц, О; Митровиц, Л; Несковиц-Константиновиц, З; Николиц-Вукосављевиц, Д;
dc.citation.volume20
dc.citation.issue2
dc.citation.spage81
dc.citation.epage87
dc.identifier.wos000169271600003
dc.citation.rankM23


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