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dc.creatorJovanovic, MS
dc.creatorBrboric, J
dc.creatorVladimirov, S
dc.creatorSuturkova, L
dc.date.accessioned2018-03-01T18:54:04Z
dc.date.available2018-03-01T18:54:04Z
dc.date.issued2000
dc.identifier.issn0236-5731 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2380
dc.description.abstractThe partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.en
dc.rightsrestrictedAccessen
dc.sourceJournal of Radioanalytical and Nuclear Chemistryen
dc.titleCorrelation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivativesen
dc.typearticleen
dcterms.abstractЈовановиц, МС; Брбориц, Ј; Владимиров, С; Сутуркова, Л;
dc.citation.volume245
dc.citation.issue3
dc.citation.spage555
dc.citation.epage560
dc.identifier.wos000089673500015
dc.identifier.doi10.1023/A:1006709310527
dc.citation.rankM22
dc.identifier.scopus2-s2.0-0033802493


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