Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy
Само за регистроване кориснике
2015
Аутори
Radović, MagdalenaCalatayud, Maria Pilar
Goya, Gerardo F.
Ricardo Ibarra, Manuel
Antić, Bratislav
Spasojević, Vojislav
Nikolić, Nadežda S.
Janković, Drina
Mirković, Marija D.
Vranješ-Đurić, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 +/- 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 +/- 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe3O4-PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of Y-90-MNPs were compared. Both types of MNPs were Y-90-labeled in reproducible high yield ( GT 97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the live...r (14.58%ID/g for Y-90-Fe3O4-Naked MNPs and 19.61%ID/g for Y-90-Fe3O4-PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of Y-90-Fe3O4-Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for Y-90-Fe3O4-PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as Y-90-Fe3O4-PEG600 MNPs constitute a great promise for multiple diagnostic-therapeutic uses combining, for example, MRI-magnetic hyperthermia and regional radiotherapy. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126-134, 2015.
Кључне речи:
magnetic nanoparticles / Y-90 / PEG / hyperthermia / radionuclide therapyИзвор:
Journal of Biomedical Materials Research. Part A, 2015, 103, 1, 126-134Финансирање / пројекти:
- Магнетни и радионуклидима обележени наноструктурни материјали за примене у медицини (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45015)
- Spanish Ministerio de Economia y Competitividad (MINECO) [MAT2010-19326, HelloKit INNPACTO]
DOI: 10.1002/jbm.a.35160
ISSN: 1549-3296; 1552-4965
PubMed: 24616186
WoS: 000345572100015
Scopus: 2-s2.0-84912522377
Колекције
Институција/група
VinčaTY - JOUR AU - Radović, Magdalena AU - Calatayud, Maria Pilar AU - Goya, Gerardo F. AU - Ricardo Ibarra, Manuel AU - Antić, Bratislav AU - Spasojević, Vojislav AU - Nikolić, Nadežda S. AU - Janković, Drina AU - Mirković, Marija D. AU - Vranješ-Đurić, Sanja PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/234 AB - Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 +/- 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 +/- 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe3O4-PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of Y-90-MNPs were compared. Both types of MNPs were Y-90-labeled in reproducible high yield ( GT 97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for Y-90-Fe3O4-Naked MNPs and 19.61%ID/g for Y-90-Fe3O4-PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of Y-90-Fe3O4-Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for Y-90-Fe3O4-PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as Y-90-Fe3O4-PEG600 MNPs constitute a great promise for multiple diagnostic-therapeutic uses combining, for example, MRI-magnetic hyperthermia and regional radiotherapy. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126-134, 2015. T2 - Journal of Biomedical Materials Research. Part A T1 - Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy VL - 103 IS - 1 SP - 126 EP - 134 DO - 10.1002/jbm.a.35160 ER -
@article{ author = "Radović, Magdalena and Calatayud, Maria Pilar and Goya, Gerardo F. and Ricardo Ibarra, Manuel and Antić, Bratislav and Spasojević, Vojislav and Nikolić, Nadežda S. and Janković, Drina and Mirković, Marija D. and Vranješ-Đurić, Sanja", year = "2015", abstract = "Two different types of magnetic nanoparticles (MNPs) were synthesized in order to compare their efficiency as radioactive vectors, Fe3O4-Naked (80 +/- 5 nm) and polyethylene glycol 600 diacid functionalized Fe3O4 (Fe3O4-PEG600) MNPs (46 +/- 0.6 nm). They were characterized based on the external morphology, size distribution, and colloidal and magnetic properties. The obtained specific power absorption value for Fe3O4-PEG600 MNPs was 200 W/g, indicated their potential in hyperthermia based cancer treatments. The labeling yield, in vitro stability and in vivo biodistribution profile of Y-90-MNPs were compared. Both types of MNPs were Y-90-labeled in reproducible high yield ( GT 97%). The stability of the obtained radioactive nanoparticles was evaluated in saline and human serum media in order to optimize the formulations for in vivo use. The biodistribution in Wistar rats showed different pharmacokinetic behaviors of nanoparticles: a large fraction of both injected MNPs ended in the liver (14.58%ID/g for Y-90-Fe3O4-Naked MNPs and 19.61%ID/g for Y-90-Fe3O4-PEG600 MNPs) whereas minor fractions attained in other organs. The main difference between the two types of MNPs was the higher accumulation of Y-90-Fe3O4-Naked MNPs in the lungs (12.14%ID/g vs. 2.00%ID/g for Y-90-Fe3O4-PEG600 MNPs) due to their in vivo agglomeration. The studied radiolabeled magnetic complexes such as Y-90-Fe3O4-PEG600 MNPs constitute a great promise for multiple diagnostic-therapeutic uses combining, for example, MRI-magnetic hyperthermia and regional radiotherapy. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 126-134, 2015.", journal = "Journal of Biomedical Materials Research. Part A", title = "Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy", volume = "103", number = "1", pages = "126-134", doi = "10.1002/jbm.a.35160" }
Radović, M., Calatayud, M. P., Goya, G. F., Ricardo Ibarra, M., Antić, B., Spasojević, V., Nikolić, N. S., Janković, D., Mirković, M. D.,& Vranješ-Đurić, S.. (2015). Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy. in Journal of Biomedical Materials Research. Part A, 103(1), 126-134. https://doi.org/10.1002/jbm.a.35160
Radović M, Calatayud MP, Goya GF, Ricardo Ibarra M, Antić B, Spasojević V, Nikolić NS, Janković D, Mirković MD, Vranješ-Đurić S. Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy. in Journal of Biomedical Materials Research. Part A. 2015;103(1):126-134. doi:10.1002/jbm.a.35160 .
Radović, Magdalena, Calatayud, Maria Pilar, Goya, Gerardo F., Ricardo Ibarra, Manuel, Antić, Bratislav, Spasojević, Vojislav, Nikolić, Nadežda S., Janković, Drina, Mirković, Marija D., Vranješ-Đurić, Sanja, "Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy" in Journal of Biomedical Materials Research. Part A, 103, no. 1 (2015):126-134, https://doi.org/10.1002/jbm.a.35160 . .