Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism
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Veljković, VeljkoGlišić, Sanja
Veljković, Nevena V.
Bojić, Tijana
Dietrich, Ursula
Perović, Vladimir R.
Colombatti, Alfonso
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Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies o...n the cardioprotective effect of influenza vaccines. (C) 2014 Elsevier Ltd. All rights reserved.
Keywords:
Influenza vaccine / Cardio-vascular diseases / Hemagglutinin / Bradykinin 2 receptor / Protein-protein interactionSource:
Vaccine, 2014, 32, 48, 6569-6575Funding / projects:
- Application of the EIIP/ISM bioinformatics platform in discovery of novel therapeutic targets and potential therapeutic molecules (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.1016/j.vaccine.2014.07.007
ISSN: 0264-410X
PubMed: 25045818
WoS: 000345469000038
Scopus: 2-s2.0-84908616634
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VinčaTY - JOUR AU - Veljković, Veljko AU - Glišić, Sanja AU - Veljković, Nevena V. AU - Bojić, Tijana AU - Dietrich, Ursula AU - Perović, Vladimir R. AU - Colombatti, Alfonso PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/229 AB - Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines. (C) 2014 Elsevier Ltd. All rights reserved. T2 - Vaccine T1 - Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism VL - 32 IS - 48 SP - 6569 EP - 6575 DO - 10.1016/j.vaccine.2014.07.007 ER -
@article{ author = "Veljković, Veljko and Glišić, Sanja and Veljković, Nevena V. and Bojić, Tijana and Dietrich, Ursula and Perović, Vladimir R. and Colombatti, Alfonso", year = "2014", abstract = "Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines. (C) 2014 Elsevier Ltd. All rights reserved.", journal = "Vaccine", title = "Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism", volume = "32", number = "48", pages = "6569-6575", doi = "10.1016/j.vaccine.2014.07.007" }
Veljković, V., Glišić, S., Veljković, N. V., Bojić, T., Dietrich, U., Perović, V. R.,& Colombatti, A.. (2014). Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism. in Vaccine, 32(48), 6569-6575. https://doi.org/10.1016/j.vaccine.2014.07.007
Veljković V, Glišić S, Veljković NV, Bojić T, Dietrich U, Perović VR, Colombatti A. Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism. in Vaccine. 2014;32(48):6569-6575. doi:10.1016/j.vaccine.2014.07.007 .
Veljković, Veljko, Glišić, Sanja, Veljković, Nevena V., Bojić, Tijana, Dietrich, Ursula, Perović, Vladimir R., Colombatti, Alfonso, "Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism" in Vaccine, 32, no. 48 (2014):6569-6575, https://doi.org/10.1016/j.vaccine.2014.07.007 . .