Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate
Apstrakt
The in vitro stability of Tc-99m(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of Tc-99m in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of Tc-99m-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq Tc-99m/ml) but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 mu g/ml keeps the content of Tc-99m-pertechnetate below 1% during six hours after labeling, even in solutions of high radioactive concentrations (740-814 MBq/ml). Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of Tc-99m-pertechnetate below 5% during six hours.
Ključne reči:
pyrophosphate / technetium-99m / ascorbic acid / gentisic acid / chemical stabilizationIzvor:
Journal of the Serbian Chemical Society, 1999, 64, 5-6, 375-380Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Vučina, Jurij L. PY - 1999 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2257 AB - The in vitro stability of Tc-99m(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of Tc-99m in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of Tc-99m-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq Tc-99m/ml) but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 mu g/ml keeps the content of Tc-99m-pertechnetate below 1% during six hours after labeling, even in solutions of high radioactive concentrations (740-814 MBq/ml). Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of Tc-99m-pertechnetate below 5% during six hours. T2 - Journal of the Serbian Chemical Society T1 - Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate VL - 64 IS - 5-6 SP - 375 EP - 380 UR - https://hdl.handle.net/21.15107/rcub_vinar_2257 ER -
@article{ author = "Vučina, Jurij L.", year = "1999", abstract = "The in vitro stability of Tc-99m(Sn)-pyrophosphate solution was examined in dependence on the preparation conditions of the samples, the radioactive concentration of Tc-99m in the kit and the time elapsed after labeling. The samples without any protection are highly unstable. The formation of Tc-99m-pertechnetate does not depend on the radioactive concentration. Nitrogen purging provides protection in the case of low radioactive concentrations (37 MBq Tc-99m/ml) but exhibits no effect at higher concentrations. The best stabilization was achieved by using ascorbic acid. A concentration of 60 mu g/ml keeps the content of Tc-99m-pertechnetate below 1% during six hours after labeling, even in solutions of high radioactive concentrations (740-814 MBq/ml). Gentisic acid is less effective. Concentrations about ten times higher than required using ascorbic acid are needed to keep the content of Tc-99m-pertechnetate below 5% during six hours.", journal = "Journal of the Serbian Chemical Society", title = "Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate", volume = "64", number = "5-6", pages = "375-380", url = "https://hdl.handle.net/21.15107/rcub_vinar_2257" }
Vučina, J. L.. (1999). Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate. in Journal of the Serbian Chemical Society, 64(5-6), 375-380. https://hdl.handle.net/21.15107/rcub_vinar_2257
Vučina JL. Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate. in Journal of the Serbian Chemical Society. 1999;64(5-6):375-380. https://hdl.handle.net/21.15107/rcub_vinar_2257 .
Vučina, Jurij L., "Influence of the radioactive concentration of the in vitro stability of Tc-99m(Sn)-pyrophosphate" in Journal of the Serbian Chemical Society, 64, no. 5-6 (1999):375-380, https://hdl.handle.net/21.15107/rcub_vinar_2257 .