New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
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Jovanović, Moma S.Brborić, Jasmina
Vladimirov, Sote
Zmbova, B
Vuksanovic, LJ
Zivanov-Stakic, D
Obradović, V
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A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
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Journal of Radioanalytical and Nuclear Chemistry, 1999, 240, 1, 321-324
DOI: 10.1007/BF02349171
ISSN: 0236-5731
WoS: 000080027500044
Scopus: 2-s2.0-0032960102
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VinčaTY - JOUR AU - Jovanović, Moma S. AU - Brborić, Jasmina AU - Vladimirov, Sote AU - Zmbova, B AU - Vuksanovic, LJ AU - Zivanov-Stakic, D AU - Obradović, V PY - 1999 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2246 AB - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging VL - 240 IS - 1 SP - 321 EP - 324 DO - 10.1007/BF02349171 ER -
@article{ author = "Jovanović, Moma S. and Brborić, Jasmina and Vladimirov, Sote and Zmbova, B and Vuksanovic, LJ and Zivanov-Stakic, D and Obradović, V", year = "1999", abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging", volume = "240", number = "1", pages = "321-324", doi = "10.1007/BF02349171" }
Jovanović, M. S., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanovic, L., Zivanov-Stakic, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry, 240(1), 321-324. https://doi.org/10.1007/BF02349171
Jovanović MS, Brborić J, Vladimirov S, Zmbova B, Vuksanovic L, Zivanov-Stakic D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324. doi:10.1007/BF02349171 .
Jovanović, Moma S., Brborić, Jasmina, Vladimirov, Sote, Zmbova, B, Vuksanovic, LJ, Zivanov-Stakic, D, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324, https://doi.org/10.1007/BF02349171 . .