Show simple item record

dc.creatorPrljić, Jelena
dc.creatorVeljković, Nevena V.
dc.creatorDoliana, R
dc.creatorColombatti, A
dc.creatorJohnson, E
dc.creatorMetlaš, Radmila
dc.creatorVeljković, Veljko
dc.date.accessioned2018-03-01T18:40:51Z
dc.date.available2018-03-01T18:40:51Z
dc.date.issued1999
dc.identifier.issn0264-410X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/2230
dc.description.abstractBecause of a sequence similarity between the HIV-1 envelope glycoprotein gp120 and the variable region of human immunoglobulins, we have suggested that the use of this protein as a vaccine component could strongly influence the host immune system, making it more vulnerable to HIV, and in the long term, accelerate disease progression in asymptomatic HIV patients. Using a chimeric primer consisting of the nucleotide sequence derived from the HIV-1 env gene coding for the second conserved region of gp120, and the highly conserved sequence derived from the human immunoglobulin gene coding for the VHIII domain, we have identified in sera of AIDS patients HIV-I field isolates carrying the complete and active Chi recombinational hot spot (GCTGGTGG). We have also demonstrated in vivo recombination between the HIV-I gene coding for the central portion of the gp120 involving the V3 loop and the bacterial gene coding for the clp protease. These results strongly support and reinforce the previous contention and the serious concern that AIDS vaccine candidates carrying the HIV-1 env gene on viral and bacterial vectors, could result in the generation of new pathogens with unpredictable effects on the immune system. (C) 1999 Elsevier Science Ltd. All rights reserved.en
dc.rightsrestrictedAccessen
dc.sourceVaccineen
dc.titleIdentification of an active Chi recombinational hot spot within the HIV-1 envelope gene: consequences for development of AIDS vaccinesen
dc.typearticleen
dcterms.abstractЦоломбатти, A; Јохнсон, Е; Прљиц, Ј; Долиана, Р; Вељковић Невена В.; Метлас Радмила; Вељковић Вељко;
dc.citation.volume17
dc.citation.issue11-12
dc.citation.spage1462
dc.citation.epage1467
dc.identifier.wos000079123200022
dc.identifier.doi10.1016/S0264-410X(98)00373-9
dc.citation.rankM21a
dc.identifier.pmid10195782
dc.identifier.scopus2-s2.0-0033577341


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record