Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology
Abstract
A modified Tc-99m(Sn)-pyrophosphate (PyP) kit for the application in nuclear cardiology (radioventriculography, angiocardiography, scintigraphy of blood pool) was developed. Each vial contains 12 mg PyP (Na4P2O7), 4 mg SnCl2. 2H(2)O, 2.5 mg gentisic acid and IO mg NaCl. The reconstitution is performed by dissolving the lyophilized kit in 3 mi 0.9% NaCl. In comparison with the standard pyrophosphate kit for bone scanning and detection of miocardial infarction, it contains an increased amount of Sn(Il) so that the molar ratio ligand/reductant is lowered from 25 to 2.5. The radiochemical analyses showed that the radiochemical purity of the labeled kit is high ( GT 90%) during three hours after addition of Tc-99m-activity. The shelf-life of the inactive freeze-dried preparation is up to four months providing that it is kept in vacuum and at appropriate temperature (2-8 degrees C). The biodistribution studies revealed increased accumulation in blood and low uptake by liver and kidneys. It w...as concluded that the modified kit performs stable and reproducible properties.
Source:
Journal of Radioanalytical and Nuclear Chemistry, 1998, 238, 1-2, 155-157
DOI: 10.1007/BF02385372
ISSN: 0236-5731
WoS: 000077948400026
Scopus: 2-s2.0-0032440261
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VinčaTY - JOUR AU - Đokić, Divna Đ. AU - Maksin, Tatjana N. AU - Vučina, Jurij L. AU - Janković, Drina PY - 1998 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2218 AB - A modified Tc-99m(Sn)-pyrophosphate (PyP) kit for the application in nuclear cardiology (radioventriculography, angiocardiography, scintigraphy of blood pool) was developed. Each vial contains 12 mg PyP (Na4P2O7), 4 mg SnCl2. 2H(2)O, 2.5 mg gentisic acid and IO mg NaCl. The reconstitution is performed by dissolving the lyophilized kit in 3 mi 0.9% NaCl. In comparison with the standard pyrophosphate kit for bone scanning and detection of miocardial infarction, it contains an increased amount of Sn(Il) so that the molar ratio ligand/reductant is lowered from 25 to 2.5. The radiochemical analyses showed that the radiochemical purity of the labeled kit is high ( GT 90%) during three hours after addition of Tc-99m-activity. The shelf-life of the inactive freeze-dried preparation is up to four months providing that it is kept in vacuum and at appropriate temperature (2-8 degrees C). The biodistribution studies revealed increased accumulation in blood and low uptake by liver and kidneys. It was concluded that the modified kit performs stable and reproducible properties. T2 - Journal of Radioanalytical and Nuclear Chemistry T1 - Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology VL - 238 IS - 1-2 SP - 155 EP - 157 DO - 10.1007/BF02385372 ER -
@article{ author = "Đokić, Divna Đ. and Maksin, Tatjana N. and Vučina, Jurij L. and Janković, Drina", year = "1998", abstract = "A modified Tc-99m(Sn)-pyrophosphate (PyP) kit for the application in nuclear cardiology (radioventriculography, angiocardiography, scintigraphy of blood pool) was developed. Each vial contains 12 mg PyP (Na4P2O7), 4 mg SnCl2. 2H(2)O, 2.5 mg gentisic acid and IO mg NaCl. The reconstitution is performed by dissolving the lyophilized kit in 3 mi 0.9% NaCl. In comparison with the standard pyrophosphate kit for bone scanning and detection of miocardial infarction, it contains an increased amount of Sn(Il) so that the molar ratio ligand/reductant is lowered from 25 to 2.5. The radiochemical analyses showed that the radiochemical purity of the labeled kit is high ( GT 90%) during three hours after addition of Tc-99m-activity. The shelf-life of the inactive freeze-dried preparation is up to four months providing that it is kept in vacuum and at appropriate temperature (2-8 degrees C). The biodistribution studies revealed increased accumulation in blood and low uptake by liver and kidneys. It was concluded that the modified kit performs stable and reproducible properties.", journal = "Journal of Radioanalytical and Nuclear Chemistry", title = "Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology", volume = "238", number = "1-2", pages = "155-157", doi = "10.1007/BF02385372" }
Đokić, D. Đ., Maksin, T. N., Vučina, J. L.,& Janković, D.. (1998). Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology. in Journal of Radioanalytical and Nuclear Chemistry, 238(1-2), 155-157. https://doi.org/10.1007/BF02385372
Đokić DĐ, Maksin TN, Vučina JL, Janković D. Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology. in Journal of Radioanalytical and Nuclear Chemistry. 1998;238(1-2):155-157. doi:10.1007/BF02385372 .
Đokić, Divna Đ., Maksin, Tatjana N., Vučina, Jurij L., Janković, Drina, "Modified pyrophosphate-Tc-99m kit for application in nuclear cardiology" in Journal of Radioanalytical and Nuclear Chemistry, 238, no. 1-2 (1998):155-157, https://doi.org/10.1007/BF02385372 . .