Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions
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1997
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Membrane vesicles loaded with [Na+], prepared from synaptosomal plasma membranes (SPM) of whole brains (WE), hippocampi (Hip) and caudate nuclei (NC) of female rats, were used to study Na+-dependent Ca2+ transport across SPM vesicles under the influence of 17 beta-estradiol (E-2) in vitro. In concentrations near to physiologic, E-2 significantly increased Ca-45(2+) uptake by SPM vesicles from all the brain tissues investigated. The maximum increase was observed for WE (21%) and Hip (33%) at 10(-9) mol/l, and for NC (31%) at 5 x 10(-9) mol/l of E-2. These results (a) confirm our earlier finding that E, in vitro modulates Na+-dependent Ca2+ transport across synaptosomal membrane in rat brain regions, and (b) suggest Na+/Ca2+ exchange as principal mechanism of the E-2-stimulated Na+-dependent Ca2+ uptake by membrane vesicles. The involvement of any ATPases as possible mediators is discussed. (C) 1997, Editrice Kurtis.
Ključne reči:
estradiol / calcium uptake / membrane vesicles / synaptosomes / ratsIzvor:
Journal of Endocrinological Investigation, 1997, 20, 11, 664-668
DOI: 10.1007/BF03348028
ISSN: 1720-8386
PubMed: 9492105
WoS: 000071767800005
Scopus: 2-s2.0-0031469187
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VinčaTY - JOUR AU - Nikezić, Gordana S. AU - Nedeljković, N. AU - Horvat, Anica AU - Kanazir, Dušan T. AU - Martinović, Jelena PY - 1997 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2108 AB - Membrane vesicles loaded with [Na+], prepared from synaptosomal plasma membranes (SPM) of whole brains (WE), hippocampi (Hip) and caudate nuclei (NC) of female rats, were used to study Na+-dependent Ca2+ transport across SPM vesicles under the influence of 17 beta-estradiol (E-2) in vitro. In concentrations near to physiologic, E-2 significantly increased Ca-45(2+) uptake by SPM vesicles from all the brain tissues investigated. The maximum increase was observed for WE (21%) and Hip (33%) at 10(-9) mol/l, and for NC (31%) at 5 x 10(-9) mol/l of E-2. These results (a) confirm our earlier finding that E, in vitro modulates Na+-dependent Ca2+ transport across synaptosomal membrane in rat brain regions, and (b) suggest Na+/Ca2+ exchange as principal mechanism of the E-2-stimulated Na+-dependent Ca2+ uptake by membrane vesicles. The involvement of any ATPases as possible mediators is discussed. (C) 1997, Editrice Kurtis. T2 - Journal of Endocrinological Investigation T1 - Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions VL - 20 IS - 11 SP - 664 EP - 668 DO - 10.1007/BF03348028 ER -
@article{ author = "Nikezić, Gordana S. and Nedeljković, N. and Horvat, Anica and Kanazir, Dušan T. and Martinović, Jelena", year = "1997", abstract = "Membrane vesicles loaded with [Na+], prepared from synaptosomal plasma membranes (SPM) of whole brains (WE), hippocampi (Hip) and caudate nuclei (NC) of female rats, were used to study Na+-dependent Ca2+ transport across SPM vesicles under the influence of 17 beta-estradiol (E-2) in vitro. In concentrations near to physiologic, E-2 significantly increased Ca-45(2+) uptake by SPM vesicles from all the brain tissues investigated. The maximum increase was observed for WE (21%) and Hip (33%) at 10(-9) mol/l, and for NC (31%) at 5 x 10(-9) mol/l of E-2. These results (a) confirm our earlier finding that E, in vitro modulates Na+-dependent Ca2+ transport across synaptosomal membrane in rat brain regions, and (b) suggest Na+/Ca2+ exchange as principal mechanism of the E-2-stimulated Na+-dependent Ca2+ uptake by membrane vesicles. The involvement of any ATPases as possible mediators is discussed. (C) 1997, Editrice Kurtis.", journal = "Journal of Endocrinological Investigation", title = "Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions", volume = "20", number = "11", pages = "664-668", doi = "10.1007/BF03348028" }
Nikezić, G. S., Nedeljković, N., Horvat, A., Kanazir, D. T.,& Martinović, J.. (1997). Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions. in Journal of Endocrinological Investigation, 20(11), 664-668. https://doi.org/10.1007/BF03348028
Nikezić GS, Nedeljković N, Horvat A, Kanazir DT, Martinović J. Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions. in Journal of Endocrinological Investigation. 1997;20(11):664-668. doi:10.1007/BF03348028 .
Nikezić, Gordana S., Nedeljković, N., Horvat, Anica, Kanazir, Dušan T., Martinović, Jelena, "Estradiol in vitro modulates Na+-dependent Ca2+ uptake by synaptic plasma membrane vesicles of rat brain regions" in Journal of Endocrinological Investigation, 20, no. 11 (1997):664-668, https://doi.org/10.1007/BF03348028 . .