Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels
Abstract
The apolipoprotein B (apoB) signal peptide polymorphism was studied in unrelated healthy individuals. A total of 232 women and 222 men were analyzed separately. The relative frequencies of Del allele in women and men were 0.42 and 0.37, respectively. More heterozygous individuals were detected in comparison with other populations, using a modified silver staining method on polyacrylamide gel for visualization of Ins and Del alleles. There was no statistically significant difference in mean lipid levels adjusted for age, BMI, smoking habit and blood pressure between the three Ins/Del genotypes in both samples (ANOVA). Therefore, no differences were shown in the genotype frequency distribution throughout the lipid quartiles. (C) 1997 Elsevier Science B.V.
Keywords:
lipids / apoB gene / polymorphism / signal peptide / PCRSource:
Clinica Chimica Acta, 1997, 263, 1, 57-65
DOI: 10.1016/S0009-8981(97)06556-X
ISSN: 0009-8981
PubMed: 9247728
WoS: A1997XM57900006
Scopus: 2-s2.0-13744265234
Collections
Institution/Community
VinčaTY - JOUR AU - Glišić, Sanja AU - Prljić, Jelena AU - Radovanovic, N AU - Alavantić, Dragan PY - 1997 UR - https://vinar.vin.bg.ac.rs/handle/123456789/2076 AB - The apolipoprotein B (apoB) signal peptide polymorphism was studied in unrelated healthy individuals. A total of 232 women and 222 men were analyzed separately. The relative frequencies of Del allele in women and men were 0.42 and 0.37, respectively. More heterozygous individuals were detected in comparison with other populations, using a modified silver staining method on polyacrylamide gel for visualization of Ins and Del alleles. There was no statistically significant difference in mean lipid levels adjusted for age, BMI, smoking habit and blood pressure between the three Ins/Del genotypes in both samples (ANOVA). Therefore, no differences were shown in the genotype frequency distribution throughout the lipid quartiles. (C) 1997 Elsevier Science B.V. T2 - Clinica Chimica Acta T1 - Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels VL - 263 IS - 1 SP - 57 EP - 65 DO - 10.1016/S0009-8981(97)06556-X ER -
@article{ author = "Glišić, Sanja and Prljić, Jelena and Radovanovic, N and Alavantić, Dragan", year = "1997", abstract = "The apolipoprotein B (apoB) signal peptide polymorphism was studied in unrelated healthy individuals. A total of 232 women and 222 men were analyzed separately. The relative frequencies of Del allele in women and men were 0.42 and 0.37, respectively. More heterozygous individuals were detected in comparison with other populations, using a modified silver staining method on polyacrylamide gel for visualization of Ins and Del alleles. There was no statistically significant difference in mean lipid levels adjusted for age, BMI, smoking habit and blood pressure between the three Ins/Del genotypes in both samples (ANOVA). Therefore, no differences were shown in the genotype frequency distribution throughout the lipid quartiles. (C) 1997 Elsevier Science B.V.", journal = "Clinica Chimica Acta", title = "Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels", volume = "263", number = "1", pages = "57-65", doi = "10.1016/S0009-8981(97)06556-X" }
Glišić, S., Prljić, J., Radovanovic, N.,& Alavantić, D.. (1997). Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels. in Clinica Chimica Acta, 263(1), 57-65. https://doi.org/10.1016/S0009-8981(97)06556-X
Glišić S, Prljić J, Radovanovic N, Alavantić D. Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels. in Clinica Chimica Acta. 1997;263(1):57-65. doi:10.1016/S0009-8981(97)06556-X .
Glišić, Sanja, Prljić, Jelena, Radovanovic, N, Alavantić, Dragan, "Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels" in Clinica Chimica Acta, 263, no. 1 (1997):57-65, https://doi.org/10.1016/S0009-8981(97)06556-X . .