Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats
Nema prikaza
Autori
Pajović, Snežana B.Saičić, Zorica S.
Spasić, Mihajlo
Petrović, Vojislav M.
Martinović, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 mu g estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.
Ključne reči:
superoxide dismutase / brain / progesterone / estradiol / ratsIzvor:
Experientia, 1996, 52, 3, 221-224
DOI: 10.1007/BF01920710
ISSN: 0014-4754
PubMed: 8631389
WoS: A1996UC55500004
Scopus: 2-s2.0-0029664529
Institucija/grupa
VinčaTY - JOUR AU - Pajović, Snežana B. AU - Saičić, Zorica S. AU - Spasić, Mihajlo AU - Petrović, Vojislav M. AU - Martinović, Jelena PY - 1996 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1969 AB - The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 mu g estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats. T2 - Experientia T1 - Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats VL - 52 IS - 3 SP - 221 EP - 224 DO - 10.1007/BF01920710 UR - https://hdl.handle.net/21.15107/rcub_vinar_1969 ER -
@article{ author = "Pajović, Snežana B. and Saičić, Zorica S. and Spasić, Mihajlo and Petrović, Vojislav M. and Martinović, Jelena", year = "1996", abstract = "The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 mu g estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.", journal = "Experientia", title = "Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats", volume = "52", number = "3", pages = "221-224", doi = "10.1007/BF01920710", url = "https://hdl.handle.net/21.15107/rcub_vinar_1969" }
Pajović, S. B., Saičić, Z. S., Spasić, M., Petrović, V. M.,& Martinović, J.. (1996). Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats. in Experientia, 52(3), 221-224. https://doi.org/10.1007/BF01920710 https://hdl.handle.net/21.15107/rcub_vinar_1969
Pajović SB, Saičić ZS, Spasić M, Petrović VM, Martinović J. Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats. in Experientia. 1996;52(3):221-224. doi:10.1007/BF01920710 https://hdl.handle.net/21.15107/rcub_vinar_1969 .
Pajović, Snežana B., Saičić, Zorica S., Spasić, Mihajlo, Petrović, Vojislav M., Martinović, Jelena, "Effects of progesterone and estradiol benzoate on superoxide dismutase activity in the brain of male rats" in Experientia, 52, no. 3 (1996):221-224, https://doi.org/10.1007/BF01920710 ., https://hdl.handle.net/21.15107/rcub_vinar_1969 .