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dc.creatorNikezic, G
dc.creatorHorvat, Anica
dc.creatorNedeljkovic, N
dc.creatorMartinović, Jelena
dc.date.accessioned2018-03-01T18:11:40Z
dc.date.available2018-03-01T18:11:40Z
dc.date.issued1996
dc.identifier.issn0014-4754 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1968
dc.description.abstractEffects of 17 beta-estradiol (E(2)) in vitro on Na-dependent Ca2+ efflux from, and depolarization-induced Ca2+ uptake into, the nerve cell were studied with the use of synaptosomes isolated from the brain stem, mesencephalic reticular formation (MRF), caudate nucleus and the hippocampus of long-term ovariectomized adult female rats. It was found that E(2) (1) at a concentration of 10 nM or lower, stimulates Na-dependent Ca2+ efflux in the caudate nucleus and hippocampus, and does not affect the efflux in MRF and brain stem; (2) at concentrations above 10 nM has no effect on the Ca2+ efflux in any of the four structures investigated; and (3) produces a biphasic effect on the depolarization-induced Ca2+ uptake, increasing it in all structures except MRF at 10 nM concentration, and decreasing it at concentrations higher than 10 nM, irrespective of the structure investigated. These results suggest that E(2), acting at extranuclear sites, modulates synaptic transmission via alterations of Ca2+ transport mechanisms in nerve endings.en
dc.rightsrestrictedAccessen
dc.sourceExperientiaen
dc.subjectestradiolen
dc.subjectcalcium transporten
dc.subjectsynaptosomesen
dc.subjectbrainen
dc.subjectraten
dc.title17 beta-Estradiol in vitro affects Na-dependent and depolarization-induced Ca2+ transport in rat brain synaptosomesen
dc.typearticleen
dcterms.abstractНедељковиц, Н; Хорват, Aница; Никезиц, Г; Мартиновић Јелена;
dc.citation.volume52
dc.citation.issue3
dc.citation.spage217
dc.citation.epage220
dc.identifier.wosA1996UC55500003
dc.identifier.pmid8631388


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