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dc.creatorDronjak, Slađana
dc.creatorStefanović, Bojana
dc.creatorJovanović, Predrag
dc.creatorSpasojević, Nataša
dc.creatorJankovic, Milica
dc.creatorJeremic, Ivica
dc.creatorHoffmann, Markus
dc.date.accessioned2018-03-01T18:08:18Z
dc.date.available2018-03-01T18:08:18Z
dc.date.issued2017
dc.identifier.issn1566-0702 (print)
dc.identifier.issn1872-7484 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1929
dc.description.abstractBaseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats. In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline. During the chronic phase, reduced expression of beta(1)-adrenoceptor and decreased efficiency of noradrenaline reuptake contribute to progressive damage of the myocardium and limits heart efficiency.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsrestrictedAccessen
dc.sourceAutonomic Neuroscience: Basic and Clinicalen
dc.subjectPristaneen
dc.subjectRheumatoid arthritisen
dc.subjectHeart ventriclesen
dc.subjectNoradrenalineen
dc.subjectGene expressionen
dc.subjectRatsen
dc.titleAltered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritisen
dc.typearticleen
dcterms.abstractХоффманн, Маркус; Јанковиц, Милица; Јеремиц, Ивица; Дроњак Слађана; Стефановић Бојана; Јовановић Предраг; Спасојевић Наташа;
dc.citation.volume208
dc.citation.spage165
dc.citation.epage169
dc.identifier.wos000423642600023
dc.identifier.doi10.1016/j.autneu.2017.10.003
dc.identifier.pmid29029974
dc.identifier.scopus2-s2.0-85030841700


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