Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis
Само за регистроване кориснике
2017
Аутори
Dronjak, SlađanaStefanović, Bojana
Jovanović, Predrag
Spasojević, Nataša
Janković, Milica
Jeremić, Ivica
Hoffmann, Markus
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats. In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline. During the chronic phase, reduced expression of beta(1)-adrenoceptor and decreased efficiency of noradrena...line reuptake contribute to progressive damage of the myocardium and limits heart efficiency.
Кључне речи:
Pristane / Rheumatoid arthritis / Heart ventricles / Noradrenaline / Gene expression / RatsИзвор:
Autonomic Neuroscience: Basic and Clinical, 2017, 208, 165-169Финансирање / пројекти:
DOI: 10.1016/j.autneu.2017.10.003
ISSN: 1566-0702; 1872-7484
PubMed: 29029974
WoS: 000423642600023
Scopus: 2-s2.0-85030841700
Колекције
Институција/група
VinčaTY - JOUR AU - Dronjak, Slađana AU - Stefanović, Bojana AU - Jovanović, Predrag AU - Spasojević, Nataša AU - Janković, Milica AU - Jeremić, Ivica AU - Hoffmann, Markus PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1929 AB - Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats. In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline. During the chronic phase, reduced expression of beta(1)-adrenoceptor and decreased efficiency of noradrenaline reuptake contribute to progressive damage of the myocardium and limits heart efficiency. T2 - Autonomic Neuroscience: Basic and Clinical T1 - Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis VL - 208 SP - 165 EP - 169 DO - 10.1016/j.autneu.2017.10.003 ER -
@article{ author = "Dronjak, Slađana and Stefanović, Bojana and Jovanović, Predrag and Spasojević, Nataša and Janković, Milica and Jeremić, Ivica and Hoffmann, Markus", year = "2017", abstract = "Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats. In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline. During the chronic phase, reduced expression of beta(1)-adrenoceptor and decreased efficiency of noradrenaline reuptake contribute to progressive damage of the myocardium and limits heart efficiency.", journal = "Autonomic Neuroscience: Basic and Clinical", title = "Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis", volume = "208", pages = "165-169", doi = "10.1016/j.autneu.2017.10.003" }
Dronjak, S., Stefanović, B., Jovanović, P., Spasojević, N., Janković, M., Jeremić, I.,& Hoffmann, M.. (2017). Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis. in Autonomic Neuroscience: Basic and Clinical, 208, 165-169. https://doi.org/10.1016/j.autneu.2017.10.003
Dronjak S, Stefanović B, Jovanović P, Spasojević N, Janković M, Jeremić I, Hoffmann M. Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis. in Autonomic Neuroscience: Basic and Clinical. 2017;208:165-169. doi:10.1016/j.autneu.2017.10.003 .
Dronjak, Slađana, Stefanović, Bojana, Jovanović, Predrag, Spasojević, Nataša, Janković, Milica, Jeremić, Ivica, Hoffmann, Markus, "Altered cardiac gene expression of noradrenaline enzymes, transporter and beta-adrenoceptors in rat model of rheumatoid arthritis" in Autonomic Neuroscience: Basic and Clinical, 208 (2017):165-169, https://doi.org/10.1016/j.autneu.2017.10.003 . .