Antibacterial ability of supported silver nanoparticles by functionalized hydroxyapatite with 5-aminosalicylic acid
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АуториLazić, Vesna M.
Smičiklas, Ivana D.
Marković, Jelena P.
Ahrenkiel, Scott Phillip
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Antimicrobial performance of silver nanoparticles supported by functionalized hydroxyapatite with 5-aminosalycile acid was tested against Gram-negative bacteria E. coli, Gram-positive bacteria S. aureus and yeast C. albicans. Thorough characterization of materials (electron microscopy, nitrogen adsorption desorption isotherms, diffuse reflectance spectroscopy) followed each step during the course of nanocomposite preparation. Synthesized powder consists of rod-like hydroxyapatite particles (40-60 x 10-20 nm, length x diameter) decorated with nano-sized spherical silver particles whose content in nanocomposite was found to be 1.9 wt.-%. Concentration- and time-dependent bacterial reduction data indicated that use of silver nanoparticles even at concentration as low as 1 mu g mL(-1) lead to complete reduction of both bacteria (E. coli and S. aureus). On the other hand, non-toxic behavior of nanocomposite in broad concentration range (0.05-2.0 mg mL(-1)) was found towards C albicans. Succ...essful inactivation of E. coli and S. aureus in five repeated cycles proved that synthesized nanocomposite can perform under long-run working conditions. (C) 2017 Elsevier Ltd. All rights reserved.