Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
Authors
Lavtar, PolonaRudolf, Gorazd
Maver, Aleš
Hodžić, Alenka
Starčević Čizmarević, Nada
Živković, Maja
Jazbec, Sasa Sega
Klemenc-Ketiš, Zalika
Kapović, Miljenko
Dinčić, Evica
Raičević, Ranko
Sepčić, Juraj
Lovrečić, Luca
Stanković, Aleksandra
Ristić, Smiljana
Peterlin, Borut
Article (Published version)
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Show full item recordAbstract
Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that gene...tic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.
Source:
PLOS One, 2018, 13, 1, e0190601-Funding / projects:
- Ministry of Science and Technology, Ljubljana, Republic of Slovenia [J3-3628]
DOI: 10.1371/journal.pone.0190601
ISSN: 1932-6203
PubMed: 29324865
WoS: 000419952400042
Scopus: 2-s2.0-85040364302
Institution/Community
VinčaTY - JOUR AU - Lavtar, Polona AU - Rudolf, Gorazd AU - Maver, Aleš AU - Hodžić, Alenka AU - Starčević Čizmarević, Nada AU - Živković, Maja AU - Jazbec, Sasa Sega AU - Klemenc-Ketiš, Zalika AU - Kapović, Miljenko AU - Dinčić, Evica AU - Raičević, Ranko AU - Sepčić, Juraj AU - Lovrečić, Luca AU - Stanković, Aleksandra AU - Ristić, Smiljana AU - Peterlin, Borut PY - 2018 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1913 AB - Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis. T2 - PLOS One T1 - Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis VL - 13 IS - 1 SP - e0190601 DO - 10.1371/journal.pone.0190601 ER -
@article{ author = "Lavtar, Polona and Rudolf, Gorazd and Maver, Aleš and Hodžić, Alenka and Starčević Čizmarević, Nada and Živković, Maja and Jazbec, Sasa Sega and Klemenc-Ketiš, Zalika and Kapović, Miljenko and Dinčić, Evica and Raičević, Ranko and Sepčić, Juraj and Lovrečić, Luca and Stanković, Aleksandra and Ristić, Smiljana and Peterlin, Borut", year = "2018", abstract = "Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.", journal = "PLOS One", title = "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis", volume = "13", number = "1", pages = "e0190601", doi = "10.1371/journal.pone.0190601" }
Lavtar, P., Rudolf, G., Maver, A., Hodžić, A., Starčević Čizmarević, N., Živković, M., Jazbec, S. S., Klemenc-Ketiš, Z., Kapović, M., Dinčić, E., Raičević, R., Sepčić, J., Lovrečić, L., Stanković, A., Ristić, S.,& Peterlin, B.. (2018). Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. in PLOS One, 13(1), e0190601. https://doi.org/10.1371/journal.pone.0190601
Lavtar P, Rudolf G, Maver A, Hodžić A, Starčević Čizmarević N, Živković M, Jazbec SS, Klemenc-Ketiš Z, Kapović M, Dinčić E, Raičević R, Sepčić J, Lovrečić L, Stanković A, Ristić S, Peterlin B. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. in PLOS One. 2018;13(1):e0190601. doi:10.1371/journal.pone.0190601 .
Lavtar, Polona, Rudolf, Gorazd, Maver, Aleš, Hodžić, Alenka, Starčević Čizmarević, Nada, Živković, Maja, Jazbec, Sasa Sega, Klemenc-Ketiš, Zalika, Kapović, Miljenko, Dinčić, Evica, Raičević, Ranko, Sepčić, Juraj, Lovrečić, Luca, Stanković, Aleksandra, Ristić, Smiljana, Peterlin, Borut, "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis" in PLOS One, 13, no. 1 (2018):e0190601, https://doi.org/10.1371/journal.pone.0190601 . .