Приказ основних података о документу
Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet
dc.creator | Jovanović, Aleksandra | |
dc.creator | Obradović, Milan M. | |
dc.creator | Sudar-Milovanović, Emina | |
dc.creator | Stewart, Alan J. | |
dc.creator | Pitt, Samantha J. | |
dc.creator | Alavantić, Dragan | |
dc.creator | Aleksić, Ema | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2018-03-01T17:58:17Z | |
dc.date.available | 2018-03-01T17:58:17Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0300-8177 | |
dc.identifier.issn | 1573-4919 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1812 | |
dc.description.abstract | The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling cascades in female rats. For this study, female Wistar rats (8 weeks old, 150-200 g) were fed a standard diet or a HF diet (balanced diet for laboratory rats enriched with 42% fat) for 10 weeks. The results show that rats fed a HF diet exhibited a decrease in phosphorylation of the alpha(1) subunit of Na+/K+-ATPase by 30% (p LT 0.05), expression of total alpha(1) subunit of Na+/K+-ATPase by 31% (p LT 0.05), and association of IRS1 with p85 subunit of PI3K by 42% (p LT 0.05), while the levels of cardiac RhoA and ROCK2 were significantly increased by 84% (p LT 0.01) and 62% (p LT 0.05), respectively. Our results suggest that a HF diet alters cardiac Na+/K+-ATPase expression via molecular mechanisms involving RhoA/ROCK and IRS-1/PI3K signalling in female rats. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS// | |
dc.rights | restrictedAccess | en |
dc.source | Molecular and Cellular Biochemistry | en |
dc.subject | High-fat diet | en |
dc.subject | Estradiol | en |
dc.subject | Na+/K+-ATPase | en |
dc.subject | Obesity | en |
dc.subject | RhoA/ROCK signalling | en |
dc.subject | Female | en |
dc.title | Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Питт, Самантха Ј.; Јовановић Aлександра; Стеwарт, Aлан Ј.; Обрадовић Милан; Aлексиц, Ема; Судар Емина; Aлавантић Драган; Исеновић Есма; | |
dc.citation.volume | 436 | |
dc.citation.issue | 1-2 | |
dc.citation.spage | 49 | |
dc.citation.epage | 58 | |
dc.identifier.wos | 000414696600006 | |
dc.identifier.doi | 10.1007/s11010-017-3077-y | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 28567564 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85020098496 |