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dc.creatorJovanović, Ljubomir J.
dc.creatorPantelić, Marija
dc.creatorProdanović, Radiša
dc.creatorVujanac, Ivan
dc.creatorĐurić, Miloje
dc.creatorTepavčević, Snežana
dc.creatorVranješ-Đurić, Sanja
dc.creatorKorićanac, Goran
dc.creatorKirovski, Danijela
dc.date.accessioned2018-03-01T17:57:56Z
dc.date.available2018-03-01T17:57:56Z
dc.date.issued2017
dc.identifier.issn0163-4984 (print)
dc.identifier.issn1559-0720 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1808
dc.description.abstractThe objective of this study was to investigate the effects of peroral administration of chromium-enriched yeast on glucose tolerance in Holstein calves, assessed by insulin signaling pathway molecule determination and intravenous glucose tolerance test (IVGTT). Twenty-four Holstein calves, aged 1 month, were chosen for the study and divided into two groups: the PoCr group (n = 12) that perorally received 0.04 mg of Cr/kg of body mass daily, for 70 days, and the NCr group (n = 12) that received no chromium supplementation. Skeletal tissue samples from each calf were obtained on day 0 and day 70 of the experiment. Chromium supplementation increased protein content of the insulin beta-subunit receptor, phosphorylation of insulin receptor substrate 1 at Tyrosine 632, phosphorylation of Akt at Serine 473, glucose transporter-4, and AMP-activated protein kinase in skeletal muscle tissue, while phosphorylation of insulin receptor substrate 1 at Serine 307 was not affected by chromium treatment. Results obtained during IVGTT, which was conducted on days 0, 30, 50, and 70, suggested an increased insulin sensitivity and, consequently, a better utilization of glucose in the PoCr group. Lower basal concentrations of glucose and insulin in the PoCr group on days 30 and 70 were also obtained. Our results indicate that chromium supplementation improves glucose utilization in calves by enhancing insulin intracellular signaling in the skeletal muscle tissue.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46002/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS//
dc.rightsrestrictedAccessen
dc.sourceBiological Trace Element Researchen
dc.subjectCalvesen
dc.subjectChromiumen
dc.subjectInsulinen
dc.subjectSignaling pathwayen
dc.subjectAMP-activated protein kinaseen
dc.titleEffect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calvesen
dc.typearticleen
dcterms.abstractЈовановиц, Љубомир; Пантелић Марија; Кировски, Данијела; Тепавчевић Снежана; Вујанац, Иван; Врањеш-Дјурић Сања; Продановиц, Радиса; Корићанац Горан; Дуриц, Милоје;
dc.citation.volume180
dc.citation.issue2
dc.citation.spage223
dc.citation.epage232
dc.identifier.wos000414196600006
dc.identifier.doi10.1007/s12011-017-1007-1
dc.identifier.pmid28378114
dc.identifier.scopus2-s2.0-85017180340


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