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dc.creatorPerić, Ivana
dc.creatorStanisavljević, Andrijana
dc.creatorGass, Peter
dc.creatorFilipović, Dragana
dc.date.accessioned2018-03-01T17:57:45Z
dc.date.available2018-03-01T17:57:45Z
dc.date.issued2017
dc.identifier.issn0940-1334 (print)
dc.identifier.issn1433-8491 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1806
dc.description.abstractExposure of an organism to chronic social isolation (CSIS) has been shown to have an important role in depression. Fluoxetine (Flx) is a first-line treatment for depression; however, its downstream mechanisms of action beyond serotonergic signaling remain ill-defined. We investigated the effect of 3 weeks of Flx (15 mg/kg/day) treatment on behavioral changes and protein expression/activity of the GSH-dependent defense system, including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GLR), and glutathione S-transferase (GST), as well as catalase (CAT), in the hippocampus of rats exposed to 6 weeks of CSIS. The subcellular distributions of nuclear factor-kappa B (NF-kappa B), as well as, cytosolic IL-1 beta and IL-6 protein expression, were also determined. CSIS induced depressive- and anxiety-like behaviors, evidenced by a decrease in sucrose preference and an increase in the number of buried marbles. Moreover, CSIS compromised redox homeostasis, targeting enzymes such as GPx, CAT, GST, and caused NF-kappa B nuclear translocation with a concomitant increase in IL-6 protein expression, without an effect on IL-1 beta. Flx treatment reversed CSIS-induced depressive- and anxiety-like behaviors, modulated GSH-dependent defense by increasing GLR and GST activity, and suppressed NF-kappa B activation and cytosolic IL-6 protein expression in socially isolated rats. The present study suggests that changes in the GSH-dependent defense system, NF-kappa B activation and increased IL-6 protein expression may have a role in social isolation-induced changes in a rat model of depression and anxiety, and contributes to our understanding of the mechanisms that underlie the antidepressant and anti-inflammatory activity of Flx in socially isolated rats.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.relationDeutsche Forschungsgemeinschaft [SFB636-TP3]
dc.rightsrestrictedAccessen
dc.sourceEuropean Archives of Psychiatry and Clinical Neuroscienceen
dc.subjectSocial isolationen
dc.subjectFluoxetineen
dc.subjectBehavioral changesen
dc.subjectGSH-dependent defense systemen
dc.subjectProinflammatory cytokinesen
dc.subjectRat hippocampusen
dc.titleFluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokinesen
dc.typearticleen
dcterms.abstractСтанисављевиц, Aндријана; Перић Ивана; Гасс, Петер; Филиповић Драгана;
dc.citation.volume267
dc.citation.issue8
dc.citation.spage737
dc.citation.epage749
dc.identifier.wos000414154100004
dc.identifier.doi10.1007/s00406-017-0807-9
dc.identifier.pmid28474231
dc.identifier.scopus2-s2.0-85018738817


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