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Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats
dc.creator | Romić, Snježana Đ. | |
dc.creator | Krskova, Katarina | |
dc.creator | Olszanecki, Rafal | |
dc.creator | Balazova, Lucia | |
dc.creator | Lory, Viktoria | |
dc.creator | Korićanac, Goran | |
dc.creator | Slamkova, Miroslava | |
dc.creator | Zorad, Stefan | |
dc.date.accessioned | 2018-03-01T17:54:05Z | |
dc.date.available | 2018-03-01T17:54:05Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0231-5882 | |
dc.identifier.issn | 1338-4325 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1764 | |
dc.description.abstract | Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-kappa B) p65 protein content in quadriceps muscle of young and old obese Zuckerfa/fa rats and their lean controls were analyzed by immunoblot to define obesity- and aging-related alterations in FA uptake, their subsequent metabolic fate and potential to activate pro-inflammatory signaling. As expected, obesity increased FAT/CD36 content in plasma membrane in quadriceps muscle of fa/fa rats. Aging increased cytosolic lipin-1 content in both, obese rats and their lean controls. Also, old obese rats had decreased level of nuclear extract lipin-lcompared to that in old lean rats. Neither obesity nor age altered NF-kappa B p65 protein content in cytosol and nuclear extract of quadriceps muscle suggesting that obesity/aging-induced changes in FA handling are not accompanied by NF-kappa B-mediated inflammation. Increase in plasma membrane FAT/CD36 content in obese rats and failure in lipin-1 export to nucleus with progression of obesity, implying an increase in FA uptake and their different channeling into lipid intermediates synthesis pathway in old fa/fa rats versus FA usage in lean rats of the same age. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS// | |
dc.relation | SAIA National Scholarship Programme of the Slovak Republic, [VEGA 2/0174/17], [APVV-15-0229], [APVV-15-0565] | |
dc.rights | restrictedAccess | en |
dc.source | General Physiology and Biophysics | en |
dc.subject | Obesity | en |
dc.subject | Aging | en |
dc.subject | Skeletal muscle | en |
dc.subject | FAT/CD36 | en |
dc.subject | Lipin-1 | en |
dc.title | Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Олсзанецки, Рафал; Ромић Сњежана; Зорад, Стефан; Корићанац Горан; Балазова, Луциа; Крскова, Катарина; Лорy, Викториа; Сламкова, Мирослава; | |
dc.citation.volume | 36 | |
dc.citation.issue | 4 | |
dc.citation.spage | 399 | |
dc.citation.epage | 406 | |
dc.identifier.wos | 000412155000005 | |
dc.identifier.doi | 10.4149/gpb_2017010 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 28653652 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85029904764 |