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dc.creatorOpacic-Galic, Vanja
dc.creatorPetrovic, Violeta
dc.creatorJokanović, Vukoman R.
dc.creatorZivkovic, Slavoljub
dc.date.accessioned2018-03-01T17:53:39Z
dc.date.available2018-03-01T17:53:39Z
dc.date.issued2017
dc.identifier.issn0370-8179 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1759
dc.description.abstractIntroduction/Objective Development of materials which could be used as biological bone substitutes is one of the most valuable and active fields of biomaterial research. The goal of the study was to research the reaction of tissue on calcium silicate-(CS) and hydroxyapatite-based (CS-HA) newly synthesized nanomaterials, after being implanted into the subcutaneous tissue of a rats and direct pulp capping of rabbit teeth. Methods The tested materials were implanted in 40 Wistar male rats, sacrificed after seven, 15, 30, and 60 days. The direct pulp capping was performed on the teeth of rabbits. Cavities were prepared on the vestibular surface of the incisors. The animals were sacrificed after 10 and 15 days. The control material was mineral trioxide aggregate (MTA). Histological analysis covered the tracking of inflammatory reaction cellular components, presence of gigantic cells, and necrosis of the tissue. Results Seven days after the implantation, the strongest inflammatory response was given by the MTA (3.3 +/- 0.48), while CS and CS-HA scored 3 +/- 0.71. After 60 days, the rate of inflammatory reactions dropped, which was the least visible with CS-HA (0.2 +/- 0.45). The least visible inflammatory reaction of the rabbits pulp tissue was spotted with the CS (1.83 +/- 0.75), than with the MTA and CS-HA (2.67 +/- 1.53, 3 +/- 0.63). Conclusion The newly synthesized materials caused a slight reaction of the subcutaneous tissue. CS-HA showed the best tissue tolerance. Nanostructural biomaterials caused a slight to moderate inflammatory reaction of the rabbits pulp tissue only in the immediate vicinity of the implanted material.en
dc.rightsopenAccessen
dc.sourceSrpski arhiv za celokupno lekarstvoen
dc.subjectbiocompatibilityen
dc.subjectcalcium silicate systemen
dc.subjecthydroxyapatiteen
dc.subjectmineral trioxide aggregateen
dc.titleHistological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials - In vivo studyen
dc.typearticleen
dcterms.abstractОпациц-Галиц, Вања; Петровиц, Виолета; Јокановић Вукоман Р.; Зивковиц, Славољуб;
dc.citation.volume145
dc.citation.issue7-8
dc.citation.spage370
dc.citation.epage377
dc.identifier.wos000411951000008
dc.identifier.doi10.2298/SARH160719063O
dc.identifier.scopus2-s2.0-85033784845
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12092/1755.pdf


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