Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?
Само за регистроване кориснике
2017
Аутори
Bundalo, Maja M.Romić, Snježana Đ.
Tepavčević, Snežana
Stojiljković, Mojca D.
Stanković, Aleksandra
Živković, Maja
Korićanac, Goran
Приказ (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to in...creased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy.
Кључне речи:
Fructose-rich diet / Heart / Insulin / EstradiolИзвор:
European Journal of Pharmacology, 2017, 811, 141-147Финансирање / пројекти:
- Улога стероидних хормона у неуроендокриној адаптацији на стрес и патофизиологији метаболичког синдрома - молекуларни механизми и клиничке импликације (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41009)
- Генетска основа хуманих васкуларних и инфламаторних болести (RS-MESTD-Basic Research (BR or ON)-175085)
DOI: 10.1016/j.ejphar.2017.06.003
ISSN: 0014-2999
PubMed: 28601616
WoS: 000410881800018
Scopus: 2-s2.0-85020390347
Колекције
Институција/група
VinčaTY - JOUR AU - Bundalo, Maja M. AU - Romić, Snježana Đ. AU - Tepavčević, Snežana AU - Stojiljković, Mojca D. AU - Stanković, Aleksandra AU - Živković, Maja AU - Korićanac, Goran PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1726 AB - Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to increased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy. T2 - European Journal of Pharmacology T1 - Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe? VL - 811 SP - 141 EP - 147 DO - 10.1016/j.ejphar.2017.06.003 ER -
@article{ author = "Bundalo, Maja M. and Romić, Snježana Đ. and Tepavčević, Snežana and Stojiljković, Mojca D. and Stanković, Aleksandra and Živković, Maja and Korićanac, Goran", year = "2017", abstract = "Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to increased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy.", journal = "European Journal of Pharmacology", title = "Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?", volume = "811", pages = "141-147", doi = "10.1016/j.ejphar.2017.06.003" }
Bundalo, M. M., Romić, S. Đ., Tepavčević, S., Stojiljković, M. D., Stanković, A., Živković, M.,& Korićanac, G.. (2017). Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?. in European Journal of Pharmacology, 811, 141-147. https://doi.org/10.1016/j.ejphar.2017.06.003
Bundalo MM, Romić SĐ, Tepavčević S, Stojiljković MD, Stanković A, Živković M, Korićanac G. Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?. in European Journal of Pharmacology. 2017;811:141-147. doi:10.1016/j.ejphar.2017.06.003 .
Bundalo, Maja M., Romić, Snježana Đ., Tepavčević, Snežana, Stojiljković, Mojca D., Stanković, Aleksandra, Živković, Maja, Korićanac, Goran, "Fructose-rich diet and insulin action in female rat heart: Estradiol friend or foe?" in European Journal of Pharmacology, 811 (2017):141-147, https://doi.org/10.1016/j.ejphar.2017.06.003 . .