Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives
Само за регистроване кориснике
2017
Аутори
Burmudžija, Adrijana Z.Muškinja, Jovana
Kosanić, Marijana
Ranković, Branislav
Novaković, Slađana B.
Đorđević, Snežana
Stanojković, Tatjana P.
Baskić, Dejan D.
Ratković, Zoran R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 m), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 m, respectively).
Кључне речи:
Cytotoxic activities / Antimicrobial activities / Dehydrozingerone / Cyclopropyl moiety / Crystal structure elucidationИзвор:
Chemistry and Biodiversity, 2017, 14, 8Финансирање / пројекти:
- Нове електрохемијске и хемијске методе у синтези органских једињења од интереса за медицину и хемију материјала (RS-MESTD-Basic Research (BR or ON)-172034)
DOI: 10.1002/cbdv.201700077
ISSN: 1612-1872; 1612-1880
WoS: 000407608400008
Scopus: 2-s2.0-85021654218
Институција/група
VinčaTY - JOUR AU - Burmudžija, Adrijana Z. AU - Muškinja, Jovana AU - Kosanić, Marijana AU - Ranković, Branislav AU - Novaković, Slađana B. AU - Đorđević, Snežana AU - Stanojković, Tatjana P. AU - Baskić, Dejan D. AU - Ratković, Zoran R. PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1680 AB - A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 m), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 m, respectively). T2 - Chemistry and Biodiversity T1 - Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives VL - 14 IS - 8 DO - 10.1002/cbdv.201700077 ER -
@article{ author = "Burmudžija, Adrijana Z. and Muškinja, Jovana and Kosanić, Marijana and Ranković, Branislav and Novaković, Slađana B. and Đorđević, Snežana and Stanojković, Tatjana P. and Baskić, Dejan D. and Ratković, Zoran R.", year = "2017", abstract = "A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 m), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 m, respectively).", journal = "Chemistry and Biodiversity", title = "Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives", volume = "14", number = "8", doi = "10.1002/cbdv.201700077" }
Burmudžija, A. Z., Muškinja, J., Kosanić, M., Ranković, B., Novaković, S. B., Đorđević, S., Stanojković, T. P., Baskić, D. D.,& Ratković, Z. R.. (2017). Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives. in Chemistry and Biodiversity, 14(8). https://doi.org/10.1002/cbdv.201700077
Burmudžija AZ, Muškinja J, Kosanić M, Ranković B, Novaković SB, Đorđević S, Stanojković TP, Baskić DD, Ratković ZR. Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives. in Chemistry and Biodiversity. 2017;14(8). doi:10.1002/cbdv.201700077 .
Burmudžija, Adrijana Z., Muškinja, Jovana, Kosanić, Marijana, Ranković, Branislav, Novaković, Slađana B., Đorđević, Snežana, Stanojković, Tatjana P., Baskić, Dejan D., Ratković, Zoran R., "Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives" in Chemistry and Biodiversity, 14, no. 8 (2017), https://doi.org/10.1002/cbdv.201700077 . .