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dc.creatorSalhi, Adil
dc.creatorEssack, Magbubah
dc.creatorAlam, Tanvir
dc.creatorBajić, Vladan P.
dc.creatorMa, Lina
dc.creatorRadovanovic, Aleksandar
dc.creatorMarchand, Benoit
dc.creatorSchmeier, Sebastian
dc.creatorZhang, Zhang
dc.creatorBajić, Vladimir B.
dc.date.accessioned2018-03-01T17:46:16Z
dc.date.available2018-03-01T17:46:16Z
dc.date.issued2017
dc.identifier.issn1547-6286 (print)
dc.identifier.issn1555-8584 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1675
dc.description.abstractNoncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA (www.cbrc.kaust.edu.sa/des_ncrna). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.relationStrategic Priority Research Program of the Chinese Academy of Sciences [XDB13040500], International Partnership Program of the Chinese Academy of Sciences [153F11KYSB20160008], National Programs for High Technology Research and Development [2015AA020108], 100 Talent Program of the Chinese Academy of Sciences
dc.rightsopenAccessen
dc.sourceRNA Biologyen
dc.subjectNoncoding RNAen
dc.subjectmicroRNAen
dc.subjectlong noncoding RNAen
dc.subjectknowledgebaseen
dc.subjectliterature-miningen
dc.subjecttext-miningen
dc.subjectdata-miningen
dc.subjectinformation integrationen
dc.subjectbioinformaticsen
dc.subjectAlzheimer diseaseen
dc.titleDES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-miningen
dc.typearticleen
dcterms.abstractМа, Лина; Ессацк, Магбубах; Марцханд, Беноит; Бајић Владан П.; Зханг, Зханг; Сцхмеиер, Себастиан; Радовановиц, Aлександар; Бајиц, Владимир Б.; Aлам, Танвир; Салхи, Aдил;
dc.citation.volume14
dc.citation.issue7
dc.citation.spage963
dc.citation.epage971
dc.identifier.wos000407258600016
dc.identifier.doi10.1080/15476286.2017.1312243
dc.identifier.pmid28387604
dc.identifier.scopus2-s2.0-85019759452
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12024/1671.pdf


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