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dc.creatorPetković, Branka B.
dc.creatorKuzmanovic, D.
dc.creatorDimitrijevic, T.
dc.creatorKrstić, Milena P.
dc.creatorStanković, Dalibor M.
dc.date.accessioned2018-03-01T17:39:23Z
dc.date.available2018-03-01T17:39:23Z
dc.date.issued2017
dc.identifier.issn1452-3981 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1596
dc.description.abstractA simple and fast method for determination of two phenothiazine drugs, chlorpromazine (CPZ) and thioridazine (TDZ), at the boron-doped diamond electrode (BDDE) was proposed. Oxidation peaks on potentials higher than 1 V were used for quantitation of investigated phenothiazines due to better selectivity over common interfering compounds in urine. Differential pulse voltammetry was applied for trace determination of CPZ and TDZ, in Britton-Robinson buffer solution at optimal pH. Under optimized DPV conditions a linear analytical curve was obtained from 1.0x10(-7) to 4.0x10(-5) M with a detection limit of 0.3x10(-7) M (for CPZ) and in the concentration range of 2x10(-7) M to 4.0x10(-5) M, with a detection limit of 1.2x10(-7)M (for TDZ). The applicability of the method was proved by determination of CPZ and TDZ by proposed procedures in spiked urine samples. The electrochemical behavior of those two important tranquilizers in different solvents was described, exploring the possibility of simultaneous determination.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45022/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationMagbiovin project [621375]
dc.rightsrestrictedAccessen
dc.sourceInternational Journal of Electrochemical Scienceen
dc.subjectvoltammetric methoden
dc.subjectchlorpromazineen
dc.subjectthioridazineen
dc.subjectboron-doped diamond electrodeen
dc.subjecthuman urineen
dc.titleNovel Strategy for Electroanalytical Detection of Antipsychotic Drugs Chlorpromazine and Thioridazine; Possibilities for Simultaneous Determinationen
dc.typearticleen
dcterms.abstractКузмановиц, Д.; Димитријевиц, Т.; Петковиц, Б. Б.; Станковић Далибор; Крстиц, М. П.;
dc.citation.volume12
dc.citation.issue5
dc.citation.spage3709
dc.citation.epage3720
dc.identifier.wos000402485100013
dc.identifier.doi10.20964/2017.05.34
dc.identifier.scopus2-s2.0-85019613952


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