New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
2017
Authors
Baroud, Afya A.Mihajlović-Lalić, Ljiljana E.
Stanković, Dalibor M.
Kajzerberger, Marijana
Van Hecke, Kristof
Grgurić-Šipka, Sanja
Savić, Aleksandar
Article (Published version)
Metadata
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A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
Keywords:
metal complex / characterization / X-ray / redox properties / biological studySource:
Journal of the Serbian Chemical Society, 2017, 82, 3, 267-275Funding / projects:
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Hercules Foundation [AUGE/11/029]
- Research Foundation - Flanders (FWO) [1.5.216.15N]
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
DOI: 10.2298/JSC170109025B
ISSN: 0352-5139
WoS: 000401126100003
Scopus: 2-s2.0-85018254497
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VinčaTY - JOUR AU - Baroud, Afya A. AU - Mihajlović-Lalić, Ljiljana E. AU - Stanković, Dalibor M. AU - Kajzerberger, Marijana AU - Van Hecke, Kristof AU - Grgurić-Šipka, Sanja AU - Savić, Aleksandar PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1569 AB - A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively. T2 - Journal of the Serbian Chemical Society T1 - New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity VL - 82 IS - 3 SP - 267 EP - 275 DO - 10.2298/JSC170109025B ER -
@article{ author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana E. and Stanković, Dalibor M. and Kajzerberger, Marijana and Van Hecke, Kristof and Grgurić-Šipka, Sanja and Savić, Aleksandar", year = "2017", abstract = "A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were GT 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.", journal = "Journal of the Serbian Chemical Society", title = "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity", volume = "82", number = "3", pages = "267-275", doi = "10.2298/JSC170109025B" }
Baroud, A. A., Mihajlović-Lalić, L. E., Stanković, D. M., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S.,& Savić, A.. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society, 82(3), 267-275. https://doi.org/10.2298/JSC170109025B
Baroud AA, Mihajlović-Lalić LE, Stanković DM, Kajzerberger M, Van Hecke K, Grgurić-Šipka S, Savić A. New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society. 2017;82(3):267-275. doi:10.2298/JSC170109025B .
Baroud, Afya A., Mihajlović-Lalić, Ljiljana E., Stanković, Dalibor M., Kajzerberger, Marijana, Van Hecke, Kristof, Grgurić-Šipka, Sanja, Savić, Aleksandar, "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity" in Journal of the Serbian Chemical Society, 82, no. 3 (2017):267-275, https://doi.org/10.2298/JSC170109025B . .