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dc.creatorAntić, Bratislav
dc.creatorBošković, Marko
dc.creatorNikodinović-Runić, Jasmina
dc.creatorMing, Yue
dc.creatorZhang, Hongguo
dc.creatorBozin, Emil S.
dc.creatorJanković, Drina
dc.creatorSpasojević, Vojislav
dc.creatorVranješ-Đurić, Sanja
dc.date.accessioned2018-03-01T17:35:34Z
dc.date.available2018-03-01T17:35:34Z
dc.date.issued2017
dc.identifier.issn0928-4931 (print)
dc.identifier.issn1873-0191 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1551
dc.description.abstractMagnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er. Here, we report on the development of citric add coated (Fe,Er)(3)O-4 nanopartides and characterization of their physico-chemical and biological properties by utilization of various complementary approaches. The synthesized MNPs had a narrow (6-7 nm) size distribution, as consistently seen in atomic pair distribution function, transmission electron microscopy, and DC magnetization measurements. The particles were found to be superparamagnetic, with a pronounced maximum in measured zero-field cooled magnetization at around 90 K. Reduction in saturation magnetization due to incorporation of 1.7% Er3+ into the Fe3O4 matrix was clearly observed. From the biological standpoint, citric acid coated (Fe,Er)(3)O-4 NPs were found to induce low toxicity both in human cell fibroblasts and in zebrafish (Danio rerio) embryos. Biodistribution pattern of the MNPs after intravenous administration in healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-labeled MNPs were predominantly found in liver (7533% ID), followed by lungs (16.70% ID) and spleen (2.83% ID). Quantitative agreement with these observations was obtained by ICP-MS elemental analysis using Er as the detected tracer. Based on the favorable physical, chemical and biological characteristics, citric add coated (Fe,Er)(3)O-4 MNPs could be further considered for the potential application as a diagnostic and/or therapeutic agent. This work also demonstrates that combined application of these techniques is a promising tool for studies of pharmacokinetics of the new MNPs in complex biological systems. (C) 2017 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45015/RS//
dc.relationInternational S and T Cooperation Program of China [2015DFG52020], US DOE, Office of Science, Office of Basic Energy Sciences (DOE-BES) [DE-SC00112704]
dc.rightsrestrictedAccessen
dc.sourceMaterials Science and Engineering. C: Materials for Biological Applicationsen
dc.subjectMagnetic nanopartideen
dc.subjectBiodistributionen
dc.subjectEmbryotoxicityen
dc.subjectRadiolabelingen
dc.subjectMNPen
dc.titleComplementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticlesen
dc.typearticleen
dcterms.abstractЗханг, Хонггуо; Aнтић Братислав; Бозин, Емил С.; Босковић Марко; Минг, Yуе; Никодиновиц-Руниц, Јасмина; Јанковић Дрина; Спасојевић Војислав; Врањеш-Дјурић Сања;
dc.citation.volume75
dc.citation.spage157
dc.citation.epage164
dc.identifier.wos000400720800019
dc.identifier.doi10.1016/j.msec.2017.02.023
dc.identifier.pmid28415449
dc.identifier.scopus2-s2.0-85013041507


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