Should We be Concerned About the Inflammatory Response to Endovascular Procedures?
Nema prikaza
Autori
Radak, Đorđe J.Đukić, Nenad
Tanasković, Slobodan
Obradović, Milan M.
Cenić-Milošević, Desanka
Isenović, Esma R.
Prikaz (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additionally, it has been shown that muscular arteries of femoropopliteal segment react to a greater extent to stent implantation, compared with elastic carotid or iliac arteries. The endovascular treatment of thoracic and abdominal aortic aneurysm is frequently followed with post-implantation inflammatory syndrome. Most recent findings point out that stent graft material plays a significant ro...le in the inflammatory response, representing a challenge for clinicians. Future studies should consider the pathophysiology of the inflammatory response associated with endovascular procedures as well as predictors and risk factors including preventive strategies and therapeutic algorithms. Although the potential role of anti-inflammatory drugs after endovascular procedures has been observed, it needs to be validated in upcoming trials. The Neutrophil Lymphocyte Ratio, platelet count, Platelet-to-Lymphocyte Ratio and other biomarkers should be considered in future trials to assess the inflammatory response after endovascular procedures. Inflammatory markers may also become therapeutic targets.
Ključne reči:
Endovascular procedures / percutaneous transluminal angioplasty / stent implantation / endovascular aortic repair / thoracic endovascular aortic repair / inflammatory responseIzvor:
Current Vascular Pharmacology, 2017, 15, 3, 230-237Finansiranje / projekti:
- Karotidna bolest u Srbiji - patološka dinamika, prevencija, dijagnostika i inovativni terapijski postupci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41002)
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.2174/1570161115666170105121900
ISSN: 1570-1611; 1875-6212
PubMed: 28056759
WoS: 000399595500005
Scopus: 2-s2.0-85019569181
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Radak, Đorđe J. AU - Đukić, Nenad AU - Tanasković, Slobodan AU - Obradović, Milan M. AU - Cenić-Milošević, Desanka AU - Isenović, Esma R. PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1522 AB - Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additionally, it has been shown that muscular arteries of femoropopliteal segment react to a greater extent to stent implantation, compared with elastic carotid or iliac arteries. The endovascular treatment of thoracic and abdominal aortic aneurysm is frequently followed with post-implantation inflammatory syndrome. Most recent findings point out that stent graft material plays a significant role in the inflammatory response, representing a challenge for clinicians. Future studies should consider the pathophysiology of the inflammatory response associated with endovascular procedures as well as predictors and risk factors including preventive strategies and therapeutic algorithms. Although the potential role of anti-inflammatory drugs after endovascular procedures has been observed, it needs to be validated in upcoming trials. The Neutrophil Lymphocyte Ratio, platelet count, Platelet-to-Lymphocyte Ratio and other biomarkers should be considered in future trials to assess the inflammatory response after endovascular procedures. Inflammatory markers may also become therapeutic targets. T2 - Current Vascular Pharmacology T1 - Should We be Concerned About the Inflammatory Response to Endovascular Procedures? VL - 15 IS - 3 SP - 230 EP - 237 DO - 10.2174/1570161115666170105121900 ER -
@article{ author = "Radak, Đorđe J. and Đukić, Nenad and Tanasković, Slobodan and Obradović, Milan M. and Cenić-Milošević, Desanka and Isenović, Esma R.", year = "2017", abstract = "Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction. Additionally, it has been shown that muscular arteries of femoropopliteal segment react to a greater extent to stent implantation, compared with elastic carotid or iliac arteries. The endovascular treatment of thoracic and abdominal aortic aneurysm is frequently followed with post-implantation inflammatory syndrome. Most recent findings point out that stent graft material plays a significant role in the inflammatory response, representing a challenge for clinicians. Future studies should consider the pathophysiology of the inflammatory response associated with endovascular procedures as well as predictors and risk factors including preventive strategies and therapeutic algorithms. Although the potential role of anti-inflammatory drugs after endovascular procedures has been observed, it needs to be validated in upcoming trials. The Neutrophil Lymphocyte Ratio, platelet count, Platelet-to-Lymphocyte Ratio and other biomarkers should be considered in future trials to assess the inflammatory response after endovascular procedures. Inflammatory markers may also become therapeutic targets.", journal = "Current Vascular Pharmacology", title = "Should We be Concerned About the Inflammatory Response to Endovascular Procedures?", volume = "15", number = "3", pages = "230-237", doi = "10.2174/1570161115666170105121900" }
Radak, Đ. J., Đukić, N., Tanasković, S., Obradović, M. M., Cenić-Milošević, D.,& Isenović, E. R.. (2017). Should We be Concerned About the Inflammatory Response to Endovascular Procedures?. in Current Vascular Pharmacology, 15(3), 230-237. https://doi.org/10.2174/1570161115666170105121900
Radak ĐJ, Đukić N, Tanasković S, Obradović MM, Cenić-Milošević D, Isenović ER. Should We be Concerned About the Inflammatory Response to Endovascular Procedures?. in Current Vascular Pharmacology. 2017;15(3):230-237. doi:10.2174/1570161115666170105121900 .
Radak, Đorđe J., Đukić, Nenad, Tanasković, Slobodan, Obradović, Milan M., Cenić-Milošević, Desanka, Isenović, Esma R., "Should We be Concerned About the Inflammatory Response to Endovascular Procedures?" in Current Vascular Pharmacology, 15, no. 3 (2017):230-237, https://doi.org/10.2174/1570161115666170105121900 . .