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dc.creatorPetrović, Sandra
dc.creatorVasić, Vesna M.
dc.creatorMitrovic, Tatjana
dc.creatorLazovic, Sasa
dc.creatorLeskovac, Andreja
dc.date.accessioned2018-03-01T17:31:37Z
dc.date.available2018-03-01T17:31:37Z
dc.date.issued2017
dc.identifier.issn0004-1254 (print)
dc.identifier.issn1848-6312 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1506
dc.description.abstractUndecylprodigiosin pigment (UPP) is reported to display cytotoxic activity towards various types of tumours. Nevertheless, its efficacy in modifying the cellular response to ionising radiation is still unknown. In this study, the radiomodulating effects of UPP were investigated. The effects of UPP were assessed in vitro by treating cultures of human peripheral blood with UPP and ionising radiation using two treatment regimens, the UPP pre-irradiation treatment and UPP post-irradiation treatment. The activity of UPP was investigated evaluating its effects on the radiation-induced micronuclei formation, cell proliferation, and induction of apoptosis. The redox modulating effects of UPP were examined measuring the catalase activity and the level of malondialdehyde, as a measure of oxidative stress. The results showed that UPP effects on cellular response to ionising radiation depend on its concentration and the timing of its administration. At low concentration, the UPP displayed radioprotective effects in. gamma-irradiated human lymphocytes while at higher concentrations, it acted as a radiosensitiser enhancing either mitotic catastrophe or apoptosis depending on the treatment regimen. The UPP modified redox processes in cells, particularly when it was employed prior to gamma-irradiation. Our data highlight the importance of further research of the potential of UPP to sensitize tumour cells to radiation therapy by inhibiting pathways that lead to treatment resistance.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS//
dc.rightsopenAccessen
dc.sourceArhiv za higijenu rada i toksikologijuen
dc.subjectapoptosisen
dc.subjectmitotic catastropheen
dc.subjectoxidative stressen
dc.subjectradiosensitisationen
dc.subjectundecylprodigiosinen
dc.titleThe impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitroen
dc.typearticleen
dcterms.abstractМитровиц, Татјана; Васић Весна М; Петровић, Сандра; Лазовиц, Саса; Лесковац Aндреја;
dc.citation.volume68
dc.citation.issue1
dc.citation.spage1
dc.citation.epage8
dc.identifier.wos000399013400001
dc.identifier.doi10.1515/aiht-2017-68-2897
dc.identifier.pmid28365670
dc.identifier.scopus2-s2.0-85017372652
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/4897/[Archives of Industrial Hygiene and Toxicology] The impact of concentration and administration time on the radiomodulating properties of undecylprodigiosin in vitro.pdf


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