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dc.creatorZlatanovic, Ivana
dc.creatorStanković, Miroslava
dc.creatorJovanovic, Vesna Stankov
dc.creatorMitic, Violeta
dc.creatorZrnzevic, Ivana
dc.creatorDordevic, Aleksandra
dc.creatorStojanovic, Gordana
dc.date.accessioned2018-03-01T17:28:05Z
dc.date.available2018-03-01T17:28:05Z
dc.date.issued2017
dc.identifier.issn0352-5139 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1466
dc.description.abstractThis paper reports for the first time the effect of an acetone extract of Umbilicaria crustulosa on the micronucleus distribution of human lymphocytes, and on the cholinesterase activity and antioxidant activity by the cupric ion reducing antioxidant capacity (CUPRAC) method. Additionally, the total phenolic compounds (TPC) and the antioxidant properties were estimated via DPPH, ABTS and TRP assays. Moreover, the antibacterial activity against two Gram-positive and three Gram-negative bacteria were determined. Acetone extract of U. crustulosa at concentration of 1 and 2 mu g mL(-1) decreased a frequency of micronuclei (MN) by 10.8 and 16.8 %, respectively, acting more or slightly less than the synthetic protector amifostine (AMF, WR-2721, 11.4 %, at concentration of 1 mu g mL(-1)). The tested extract did not inhibit cholinesterase activity nor did it exhibit activity toward the examined bacteria. The extract reduced the concentration of DPPH and ABTS radicals by 88.7 and 96.2 %, respectively. Values for total reducing power (TRP) and cupric reducing capacity (CUPRAC) were 0.6197+/-0.0166 mu g ascorbic acid equivalents (AAE) per mg of dry extract, and 19.7641+/-1.6546 mu g trolox equivalents (TE) per mg of dry extract, respectively. The total phenol content was 350.4188 +/-14.587 mu g gallic acid equivalents (GAE) per mg of dry extract. The results of the present study showed that U. crustulosa acetone extract is a promising candidate for in vivo experiments considering its antioxidant activity and protective effect on human lymphocytes.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172047/RS//
dc.rightsopenAccessen
dc.sourceJournal of the Serbian Chemical Societyen
dc.subjectmicronucleus testen
dc.subjectantioxidant activityen
dc.subjectcholinesterase inhibitionen
dc.subjectantimicrobial activityen
dc.subjectchemical compositionen
dc.titleBiological activities of Umbilicaria crustulosa (Ach.) Frey acetone extracten
dc.typearticleen
dcterms.abstractМитиц, Виолета; Јовановиц, Весна Станков; Златановиц, Ивана; Станковиц, Мирослава; Дордевиц, Aлександра; Стојановиц, Гордана; Зрнзевиц, Ивана;
dc.citation.volume82
dc.citation.issue2
dc.citation.spage141
dc.citation.epage150
dc.identifier.wos000396582200003
dc.identifier.doi10.2298/JSC161019014Z
dc.identifier.scopus2-s2.0-85015862732
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11838/1462.pdf


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