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dc.creatorPiovesan, Damiano
dc.creatorTabaro, Francesco
dc.creatorMicetic, Ivan
dc.creatorNecci, Marco
dc.creatorQuaglia, Federica
dc.creatorOldfield, Christopher J.
dc.creatorAspromonte, Maria Cristina
dc.creatorDavey, Norman E.
dc.creatorDavidović, Radoslav S.
dc.creatorDosztanyi, Zsuzsanna
dc.creatorElofsson, Arne
dc.creatorGasparini, Alessandra
dc.creatorHatos, Andras
dc.creatorKajava, Andrey V.
dc.creatorKalmar, Lajos
dc.creatorLeonardi, Emanuela
dc.creatorLazar, Tamas
dc.creatorMacedo-Ribeiro, Sandra
dc.creatorMacossay-Castillo, Mauricio
dc.creatorMeszaros, Attila
dc.creatorMinervini, Giovanni
dc.creatorMurvai, Nikoletta
dc.creatorPujols, Jordi
dc.creatorRoche, Daniel B.
dc.creatorSalladini, Edoardo
dc.creatorSchad, Eva
dc.creatorSchramm, Antoine
dc.creatorSzabo, Beata
dc.creatorTantos, Agnes
dc.creatorTonello, Fiorella
dc.creatorTsirigos, Konstantinos D.
dc.creatorVeljković, Nevena V.
dc.creatorVentura, Salvador
dc.creatorVranken, Wim
dc.creatorWarholm, Per
dc.creatorUversky, Vladimir N.
dc.creatorDunker, A. Keith
dc.creatorLonghi, Sonia
dc.creatorTompa, Peter
dc.creatorTosatto, Silvio C. E.
dc.date.accessioned2018-03-01T17:27:55Z
dc.date.available2018-03-01T17:27:55Z
dc.date.issued2017
dc.identifier.issn0305-1048 (print)
dc.identifier.issn1362-4962 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1464
dc.description.abstractThe Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance ( primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.relationCOST Action BM1405 NGP-net, ELIXIR-IIB, Hungarian Academy of Sciences [LP2014-16], Hungarian Scientific Research Fund [OTKA K 108798], AIRC Research Fellowship, Spanish Ministerio de Educacion Cultura i Deporte PhD Fellowship, Mexican National Council for Science and Technology (CONACYT) [215503], Grant PortoNeuroDRIve'i3S - Norte Portugal Regional Operational Programme (NORTE), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (ERDF), Direction Generale des Armees, Aix-Marseille University PhD Fellowship, OTKA Grant [PD-OTKA 108772], French Ministry of National Education, Research and Technology PhD Fellowship, ICREAAcademia Award, Odysseus Grant from Research Foundation Flanders (FWO) [G.0029.12], AIRC IG Grant [17753], Italian Ministry of Health [GR-2011-02347754, GR-2011-02346845], Swedish Research Council Grant [VR-NT 2012-5046]
dc.rightsopenAccessen
dc.sourceNucleic Acids Researchen
dc.titleDisProt 7.0: a major update of the database of disordered proteinsen
dc.typearticleen
dcterms.abstractМурваи, Николетта; Пиовесан, Дамиано; Вентура, Салвадор; Табаро, Францесцо; Тантос, Aгнес; Давидовић Радослав; Гаспарини, Aлессандра; Калмар, Лајос; Тсиригос, Константинос Д.; Леонарди, Емануела; Олдфиелд, Цхристопхер Ј.; Мацедо-Рибеиро, Сандра; Давеy, Норман Е.; Минервини, Гиованни; Елофссон, Aрне; Вељковић Невена В.; Тонелло, Фиорелла; Уверскy, Владимир Н.; Лонгхи, Сониа; Пујолс, Јорди; Досзтанyи, Зсузсанна; Хатос, Aндрас; Qуаглиа, Федерица; Aспромонте, Мариа Цристина; Нецци, Марцо; Мицетиц, Иван; Салладини, Едоардо; Месзарос, Aттила; Лазар, Тамас; Томпа, Петер; Вранкен, Wим; Сцхрамм, Aнтоине; Тосатто, Силвио Ц. Е.; Сцхад, Ева; Роцхе, Даниел Б.; Сзабо, Беата; Мацоссаy-Цастилло, Маурицио; Кајава, Aндреy В.; Дункер, A. Кеитх; Wархолм, Пер;
dc.citation.volume45
dc.citation.issueD1
dc.citation.spageD219
dc.citation.epageD227
dc.identifier.wos000396575500033
dc.identifier.doi10.1093/nar/gkw1056
dc.identifier.pmid27899601
dc.identifier.scopus2-s2.0-85016112986
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11836/1460.pdf


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