DisProt 7.0: a major update of the database of disordered proteins
Аутори
Piovesan, DamianoTabaro, Francesco
Micetic, Ivan
Necci, Marco
Quaglia, Federica
Oldfield, Christopher J.
Aspromonte, Maria Cristina
Davey, Norman E.
Davidović, Radoslav S.
Dosztanyi, Zsuzsanna
Elofsson, Arne
Gasparini, Alessandra
Hatos, Andras
Kajava, Andrey V.
Kalmar, Lajos
Leonardi, Emanuela
Lazar, Tamas
Macedo-Ribeiro, Sandra
Macossay-Castillo, Mauricio
Meszaros, Attila
Minervini, Giovanni
Murvai, Nikoletta
Pujols, Jordi
Roche, Daniel B.
Salladini, Edoardo
Schad, Eva
Schramm, Antoine
Szabo, Beata
Tantos, Agnes
Tonello, Fiorella
Tsirigos, Konstantinos D.
Veljković, Nevena V.
Ventura, Salvador
Vranken, Wim
Warholm, Per
Uversky, Vladimir N.
Dunker, A. Keith
Longhi, Sonia
Tompa, Peter
Tosatto, Silvio C. E.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance ( primary techniques) and a broad range of other experimental approaches (secondary techniques). Confide...nt and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.
Извор:
Nucleic Acids Research, 2017, 45, D1, D219-D227Финансирање / пројекти:
- Примена EIIP/ISM биоинформатичке платформе у откривању нових терапеутских таргета и потенцијалних терапеутских молекула (RS-173001)
- Молекуларне детерминанте за дизајн тумор маркера (RS-173049)
- COST Action BM1405 NGP-net, ELIXIR-IIB, Hungarian Academy of Sciences [LP2014-16], Hungarian Scientific Research Fund [OTKA K 108798], AIRC Research Fellowship, Spanish Ministerio de Educacion Cultura i Deporte PhD Fellowship, Mexican National Council for Science and Technology (CONACYT) [215503], Grant PortoNeuroDRIve'i3S - Norte Portugal Regional Operational Programme (NORTE), under the PORTUGAL Partnership Agreement, through the European Regional Development Fund (ERDF), Direction Generale des Armees, Aix-Marseille University PhD Fellowship, OTKA Grant [PD-OTKA 108772], French Ministry of National Education, Research and Technology PhD Fellowship, ICREAAcademia Award, Odysseus Grant from Research Foundation Flanders (FWO) [G.0029.12], AIRC IG Grant [17753], Italian Ministry of Health [GR-2011-02347754, GR-2011-02346845], Swedish Research Council Grant [VR-NT 2012-5046]
DOI: 10.1093/nar/gkw1056
ISSN: 0305-1048; 1362-4962
PubMed: 27899601
WoS: 000396575500033
Scopus: 2-s2.0-85016112986
Колекције
Институција/група
VinčaTY - JOUR AU - Piovesan, Damiano AU - Tabaro, Francesco AU - Micetic, Ivan AU - Necci, Marco AU - Quaglia, Federica AU - Oldfield, Christopher J. AU - Aspromonte, Maria Cristina AU - Davey, Norman E. AU - Davidović, Radoslav S. AU - Dosztanyi, Zsuzsanna AU - Elofsson, Arne AU - Gasparini, Alessandra AU - Hatos, Andras AU - Kajava, Andrey V. AU - Kalmar, Lajos AU - Leonardi, Emanuela AU - Lazar, Tamas AU - Macedo-Ribeiro, Sandra AU - Macossay-Castillo, Mauricio AU - Meszaros, Attila AU - Minervini, Giovanni AU - Murvai, Nikoletta AU - Pujols, Jordi AU - Roche, Daniel B. AU - Salladini, Edoardo AU - Schad, Eva AU - Schramm, Antoine AU - Szabo, Beata AU - Tantos, Agnes AU - Tonello, Fiorella AU - Tsirigos, Konstantinos D. AU - Veljković, Nevena V. AU - Ventura, Salvador AU - Vranken, Wim AU - Warholm, Per AU - Uversky, Vladimir N. AU - Dunker, A. Keith AU - Longhi, Sonia AU - Tompa, Peter AU - Tosatto, Silvio C. E. PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1464 AB - The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance ( primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins. T2 - Nucleic Acids Research T1 - DisProt 7.0: a major update of the database of disordered proteins VL - 45 IS - D1 SP - D219 EP - D227 DO - 10.1093/nar/gkw1056 ER -
@article{ author = "Piovesan, Damiano and Tabaro, Francesco and Micetic, Ivan and Necci, Marco and Quaglia, Federica and Oldfield, Christopher J. and Aspromonte, Maria Cristina and Davey, Norman E. and Davidović, Radoslav S. and Dosztanyi, Zsuzsanna and Elofsson, Arne and Gasparini, Alessandra and Hatos, Andras and Kajava, Andrey V. and Kalmar, Lajos and Leonardi, Emanuela and Lazar, Tamas and Macedo-Ribeiro, Sandra and Macossay-Castillo, Mauricio and Meszaros, Attila and Minervini, Giovanni and Murvai, Nikoletta and Pujols, Jordi and Roche, Daniel B. and Salladini, Edoardo and Schad, Eva and Schramm, Antoine and Szabo, Beata and Tantos, Agnes and Tonello, Fiorella and Tsirigos, Konstantinos D. and Veljković, Nevena V. and Ventura, Salvador and Vranken, Wim and Warholm, Per and Uversky, Vladimir N. and Dunker, A. Keith and Longhi, Sonia and Tompa, Peter and Tosatto, Silvio C. E.", year = "2017", abstract = "The Database of Protein Disorder (DisProt, URL: www.disprot.org) has been significantly updated and upgraded since its last major renewal in 2007. The current release holds information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist and function without a well-defined three-dimensional structure. We have re-curated previous entries to purge DisProt from conflicting cases, and also upgraded the functional classification scheme to reflect continuous advance in the field in the past 10 years or so. We define IDPs as proteins that are disordered along their entire sequence, i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive residues without well-defined structure. We base our assessment of disorder strictly on experimental evidence, such as X-ray crystallography and nuclear magnetic resonance ( primary techniques) and a broad range of other experimental approaches (secondary techniques). Confident and ambiguous annotations are highlighted separately. DisProt 7.0 presents classified knowledge regarding the experimental characterization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource for the research community for a better understanding structural disorder and for developing better computational tools for studying disordered proteins.", journal = "Nucleic Acids Research", title = "DisProt 7.0: a major update of the database of disordered proteins", volume = "45", number = "D1", pages = "D219-D227", doi = "10.1093/nar/gkw1056" }
Piovesan, D., Tabaro, F., Micetic, I., Necci, M., Quaglia, F., Oldfield, C. J., Aspromonte, M. C., Davey, N. E., Davidović, R. S., Dosztanyi, Z., Elofsson, A., Gasparini, A., Hatos, A., Kajava, A. V., Kalmar, L., Leonardi, E., Lazar, T., Macedo-Ribeiro, S., Macossay-Castillo, M., Meszaros, A., Minervini, G., Murvai, N., Pujols, J., Roche, D. B., Salladini, E., Schad, E., Schramm, A., Szabo, B., Tantos, A., Tonello, F., Tsirigos, K. D., Veljković, N. V., Ventura, S., Vranken, W., Warholm, P., Uversky, V. N., Dunker, A. K., Longhi, S., Tompa, P.,& Tosatto, S. C. E.. (2017). DisProt 7.0: a major update of the database of disordered proteins. in Nucleic Acids Research, 45(D1), D219-D227. https://doi.org/10.1093/nar/gkw1056
Piovesan D, Tabaro F, Micetic I, Necci M, Quaglia F, Oldfield CJ, Aspromonte MC, Davey NE, Davidović RS, Dosztanyi Z, Elofsson A, Gasparini A, Hatos A, Kajava AV, Kalmar L, Leonardi E, Lazar T, Macedo-Ribeiro S, Macossay-Castillo M, Meszaros A, Minervini G, Murvai N, Pujols J, Roche DB, Salladini E, Schad E, Schramm A, Szabo B, Tantos A, Tonello F, Tsirigos KD, Veljković NV, Ventura S, Vranken W, Warholm P, Uversky VN, Dunker AK, Longhi S, Tompa P, Tosatto SCE. DisProt 7.0: a major update of the database of disordered proteins. in Nucleic Acids Research. 2017;45(D1):D219-D227. doi:10.1093/nar/gkw1056 .
Piovesan, Damiano, Tabaro, Francesco, Micetic, Ivan, Necci, Marco, Quaglia, Federica, Oldfield, Christopher J., Aspromonte, Maria Cristina, Davey, Norman E., Davidović, Radoslav S., Dosztanyi, Zsuzsanna, Elofsson, Arne, Gasparini, Alessandra, Hatos, Andras, Kajava, Andrey V., Kalmar, Lajos, Leonardi, Emanuela, Lazar, Tamas, Macedo-Ribeiro, Sandra, Macossay-Castillo, Mauricio, Meszaros, Attila, Minervini, Giovanni, Murvai, Nikoletta, Pujols, Jordi, Roche, Daniel B., Salladini, Edoardo, Schad, Eva, Schramm, Antoine, Szabo, Beata, Tantos, Agnes, Tonello, Fiorella, Tsirigos, Konstantinos D., Veljković, Nevena V., Ventura, Salvador, Vranken, Wim, Warholm, Per, Uversky, Vladimir N., Dunker, A. Keith, Longhi, Sonia, Tompa, Peter, Tosatto, Silvio C. E., "DisProt 7.0: a major update of the database of disordered proteins" in Nucleic Acids Research, 45, no. D1 (2017):D219-D227, https://doi.org/10.1093/nar/gkw1056 . .