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dc.creatorBaroud, Afya A.
dc.creatorMihajlović-Lalić, Ljiljana E.
dc.creatorGligorijević, Nevenka N.
dc.creatorArandelovic, Sandra
dc.creatorStanković, Dalibor M.
dc.creatorRadulović, Siniša S.
dc.creatorVan Hecke, Kristof
dc.creatorSavic, Aleksandar
dc.creatorGrguric-Sipka, Sanja
dc.date.accessioned2018-03-01T17:25:42Z
dc.date.available2018-03-01T17:25:42Z
dc.date.issued2017
dc.identifier.issn0095-8972 (print)
dc.identifier.issn1029-0389 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1438
dc.description.abstractComplexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]en
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/256716/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationHercules Foundation (3D-SPACE: 3D Structural Platform Aiming for Chemical Excellence) [AUGE/11/029], Research Fund-Flanders (FWO), Magbiovin project (FP7-ERAChairs-Pilot Call) [621375]
dc.rightsrestrictedAccessen
dc.sourceJournal of Coordination Chemistryen
dc.subjectRuthenium(II) bipyridine complexesen
dc.subjectcrystal structureen
dc.subjectredox propertiesen
dc.subjectcytotoxicityen
dc.subjectDNA intercalationen
dc.titleRuthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigationen
dc.typearticleen
dcterms.abstractСавиц, Aлександар; Станковић Далибор; Ван Хецке, Кристоф; Михајловиц-Лалиц, Љиљана Е.; Бароуд, Aфyа A.; Радуловиц, Синиса; Глигоријевиц, Невенка; Гргуриц-Сипка, Сања; Aранделовиц, Сандра;
dc.citation.volume70
dc.citation.issue5
dc.citation.spage831
dc.citation.epage847
dc.identifier.wos000395175800006
dc.identifier.doi10.1080/00958972.2017.1282611
dc.identifier.scopus2-s2.0-85012257876


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