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dc.creatorSopta, Jelena
dc.creatorLujic, Nenad
dc.creatorKovacevic, Relja
dc.creatorDavidović, Radoslav S.
dc.date.accessioned2018-03-01T17:24:56Z
dc.date.available2018-03-01T17:24:56Z
dc.date.issued2016
dc.identifier.issn1233-9687 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1429
dc.description.abstractAim of the study is to determine the possible roles of p53, cyclin D1, B-catenin and Ki-67 in the increase in risk of fractures in patients with giant cell tumor of bone. The study included a total of 164 patients with giant cell tumor of bone (GCTB), 21 (12.8%) with and 143 (87.2%) without fracture. The samples were analyzed immunohistochemically for expression of Ki-67, p53, cyclin D1 and beta-catenin. According to the immunohistochemical expression of p53 and Ki-67 in mononuclear stromal cells, as well as of cyclin D1 in multinuclear giant cells, there was no significant association with immunopositivity and risk of fractures. However, our research revealed that patients with cytoplasmic expression of beta-catenin in stromal cells had three times more frequent occurrence of pathological fractures, which was highly statistically significant (chi(2) = 7.065; p = 0.008). Moreover, a highly statistically significant correlation between the nuclear expression of beta-catenin in giant cells and the incidence of pathological fractures was also found (chi(2) = 8.824; p = 0.003). The study showed that beta-catenin expression highly correlates with the incidence of pathological fractures in patients with GCTB. Taking into account that beta-catenin is closely linked to activation of the Wnt signaling pathway in GCTB pathogenesis, one could postulate that activation of the Wnt pathway is one of the contributing factors to locally destructive behavior of this tumor, as well as to the incidence of pathological fractures.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.rightsopenAccessen
dc.sourcePolish Journal of Pathologyen
dc.subjectgiant cell tumor of boneen
dc.subjectpathologic fractureen
dc.subjectbeta-cateninen
dc.subjectWnt pathwayen
dc.titleSignificance of Beta-Catenin Expression for the Incidence of Pathological Fractures in Giant Cell Tumors of Boneen
dc.typearticleen
dcterms.abstractКовацевиц, Реља; Давидовић Радослав; Сопта, Јелена; Лујиц, Ненад;
dc.citation.volume67
dc.citation.issue4
dc.citation.spage345
dc.citation.epage350
dc.identifier.wos000394202200005
dc.identifier.doi10.5114/PJP.2016.65866
dc.citation.rankM23
dc.identifier.pmid28547961
dc.identifier.scopus2-s2.0-85012170688
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11807/1425.pdf


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